Selected Dopamine Agonists/Selected Antipsychotics Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines increase the activity of dopamine in the brain. Antipsychotic medicines block the activity of dopamine in the brain.

What might happen:

Each medicine could counteract the beneficial effects of the other, so one or both medicines may not work as well.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Requip (ropinirole hydrochloride) US prescribing information. GlaxoSmithKline May, 2017.
  • 2.Sinemet (carbidopa/levodopa) US prescribing information. Merck & Co., Inc February, 2011.
  • 3.Stalevo (carbidopa; entacapone; levodopa) US Prescribing Information. Orion/Novartis October 11, 2010.
  • 4.Comtan (entacapone) US prescribing information. Orion Corporation June, 2014.
  • 5.Neupro (rotigotine transdermal system) US prescribing information. UCB Inc. September, 2015.
  • 6.Marras C, Gruneir A, Wang X, Fischer H, Gill SS, Herrmann N, Anderson GM, Hyson C, Rochon PA. Antipsychotics and mortality in Parkinsonism. Am J Geriatr Psychiatry 2012 Feb;20(2):149-58.
  • 7.Oertel WH Berardelli A Bloem Br etal. Chapter 15 - Late (complicated) Parkinson's disease in European Handbook of Neurological Management. 2011; Volume 1, 2nd Edition:237 - 267.