Loperamide/CYP3A4; CYP2C8; P-glycoprotein (P-gp) Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your medicine may increase the amount of loperamide that enters your brain.

What might happen:

You may have more side effects than normal from your loperamide, including irregular heartbeats, which may be life-threatening.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you experience excessive drowsiness, deep sleep, slowed breathing, slow pulse, nausea, vomiting, an irregular heartbeat, or have dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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