If you are:
Only When Necessary: INSUFFICIENT HUMAN DATA; TERATOGENIC IN ANIMALS AT 13 AND 146 TIMES THE MRHD
Precaution: INSUFFICIENT DATA AVAILABLE; EXCRETED IN RATS
An adult over 60:
management or monitoring precaution: General-Serious infection rates are higher in the elderly. Monitor closely. Renal-Reduce dose to 5 mg once daily for moderate-severe renal impairment. Hepatic-Reduce dose to 5 mg once daily for moderate hepatic impairment.
Giving Xeljanz to a child under 12:
management or monitoring precaution: No safety and efficacy established.