ICLUSIG Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • an infection
  • decreased function of bone marrow
  • anemia
  • decreased blood platelets
  • low levels of white blood cells
  • low levels of a type of white blood cell called neutrophils
  • a decreased number of lymphocytes in the blood
  • high blood pressure
  • obstruction of a blood vessel by a blood clot
  • a blood clot in an artery
  • escape of fluid into the lungs
  • a high alanine transaminase level
  • a high aspartate transaminase level
  • increased alkaline phosphatase

If experienced, these tend to have a Less Severe expression i

  • a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
  • stomatitis, a condition with painful swelling and sores inside the mouth
  • constipation
  • dry skin
  • joint pain
  • muscle pain
  • pain in the arms or legs
  • fever
  • low energy
  • pain
  • a skin rash
  • decreased appetite
  • headache
  • trouble breathing
  • cough
  • nausea
  • vomiting
  • diarrhea
  • intense abdominal pain

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • a condition with low thyroid hormone levels
  • a blockage of blood vessels in the retina of the eye
  • bleeding from the retina
  • a heart attack
  • supraventricular tachycardia
  • atrial fibrillation
  • supraventricular arrhythmias, a type of abnormal heart rhythm
  • chronic heart failure
  • a hemorrhage in the brain
  • a stroke
  • peripheral vascular disease
  • bleeding
  • pneumonia
  • bleeding of the stomach or intestines
  • pancreatitis

If experienced, these tend to have a Less Severe expression i

  • water retention
  • dry eye
  • backache
  • muscle spasm
  • bone pain
  • dizziness
  • difficulty sleeping
  • chills
  • fluid retention in the legs, feet, arms or hands
  • weight loss
  • a feeling of pins and needles on skin
  • macular edema

RARE side effects

If experienced, these tend to have a Severe expression i

  • overactive thyroid gland
  • dehydration
  • a clot in the small veins that carry blood to or from the retina of the eye
  • inflammation of the iris - the colored part of the eyeball
  • inflammation of the iris and ciliary body of the eye
  • clouding of the lens of the eye called cataracts
  • an ulcer of the cornea of the eye
  • extremely high blood pressure
  • a type of slowed heart rhythm disorder called heart block
  • slow heartbeat
  • subdural intracranial hemorrhage
  • a localized weakening and ballooning in an artery wall called an arterial aneurysm
  • thrombotic thrombocytopenic purpura, a type of blood disorder
  • a gastrointestinal tract fistula
  • liver failure
  • damage to the liver and inflammation
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • abnormal liver function tests
  • impaired wound healing
  • a rupture in the wall of the stomach or intestine
  • reactivation of hepatitis B infection
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • cranial nerve palsy
  • dissection of artery
  • tumor lysis syndrome

If experienced, these tend to have a Less Severe expression i

  • glaucoma, an increased pressure in the eye
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.