Contraceptives/Troleandomycin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process birth control pills properly.

What might happen:

The combination of these two medicines may cause harmful effects to your liver. You may experience yellowing of the skin or eyes, dark urine, pale stools, or itching.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. It may be necessary to change you to a different antibiotic or to a different form of birth control. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Miguet JP, Vuitton D, Allemand H, Pessayre D, Monange C, Hirsch JP, Metreau JM, Poupon R, Capron JP, Blanc F. Jaundice in women taking both troleandomycin and oral contraceptives, an outbreak in France (author's transl). Gastroenterol Clin Biol 1980 Jun-Jul;4(6-7):420-4.
  • 2.Fevery J, Van Steenbergen W, Desmet V, Deruyttere M, De Groote J. Severe intrahepatic cholestasis due to the combined intake of oral contraceptives and triacetyloleandomycin. Acta Clin Belg 1983;38(4):242-5.
  • 3.Ludden TM. Pharmacokinetic interactions of the macrolide antibiotics. Clin Pharmacokinet 1985 Jan-Feb;10(1):63-79.
  • 4.Schmider J, Greenblatt DJ, von Moltke LL, Karsov D, Vena R, Friedman HL, Shader RI. Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors. J Clin Pharmacol 1997 Mar;37(3):193-200.
  • 5.von Rosensteil NA, Adam D. Macrolide antibacterials. Drug interactions of clinical significance. Drug Saf 1995 Aug;13(2):105-22.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.