Hormonal Contraceptives/Nintedanib Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Nintedanib may lower the effectiveness of your hormonal contraceptive.
What might happen:
The effects of your birth control pills may decrease and cause breakthrough bleeding, spotting, or pregnancy. If you become pregnant, nintedanib may cause harm to the fetus. The effects of the interaction may last for three months after you stop taking nintedanib.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Use a back-up form of birth control (e.g. condoms) or an effective non-hormonal form of birth control while you are taking nintedanib and for 3 months after you stop treatment. Discuss the need to confirm that you are not pregnant or become pregnant with a pregnancy test with your healthcare professional. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Ofev (nintedanib) US prescribing information. Boehringer Ingelheim Pharmaceuticals Inc. September, 2019.
- 2.Medicines and Healthcare products Regulatory Agency. Levonorgestrel-containing emergency hormonal contraception: advice on interactions with hepatic enzyme inducers and contraceptive efficacy. available at: https://www.gov.uk/drug-safety-update/levonorgestrel-containing-emergency- hormonal-contraception-advice-on-interactions-with-hepatic-enzyme-inducers -and-contraceptive-efficacy September 15, 2016..
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.