CGMP Specific PDE Type-5 Inhibitors/Alpha-Blockers Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Avanafil, sildenafil, tadalafil, vardenafil, and alpha-blockers can lower your blood pressure.
What might happen:
Taking avanafil, sildenafil, tadalafil, or vardenafil with an alpha-blocker may result in your blood pressure becoming too low.If your blood pressure is too low, you may feel faint, dizzy, or lose consciousness.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.If you have been taking an alpha-blocker, your doctor may want you to wait to start taking avanafil, sildenafil, tadalafil, or vardenafil until you have adjusted to your alpha-blocker.If you have been taking avanafil, sildenafil, tadalafil, or vardenafil, your doctor may start you on a lower dose of an alpha-blocker.Your doctor may instruct you to separate the times you take your avanafil, sildenafil, tadalafil, or vardenafil from the time you take your alpha-blocker.Let your healthcare professionals know if you experience any dizziness or fainting.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.