This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of your medicines increase serotonin levels in your blood. Also, some antidepressants may slow down how quickly your liver processes metoclopramide.
What might happen:
High serotonin levels may cause changes in body temperature, blood pressure and behavior, leading to a medical condition called Serotonin Syndrome. Serotonin Syndrome may be life threatening. If you are taking fluoxetine or paroxetine with metoclopramide, the amount of metoclopramide in your blood may increase. This can increase the risk of abnormal, uncontrollable muscle movements called tardive dyskinesia. There is no cure for tardive dyskinesia, but symptoms may lessen or go away after you stop taking the medicines; however, the symptoms may be permanent.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you have any increase in irritability, double vision, nausea, confusion, anxiety, fever, increased muscle stiffness, or loss of consciousness.Contact your doctor right away if you develop any movements you cannot stop or control such as: lip smacking, chewing, puckering of the mouth, frowning or scowling, sticking out the tongue, blinking and moving the eyes, and shaking of the arms and/or legsYour healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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