IMBRUVICA Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • an infection
  • anemia
  • decreased blood platelets
  • low levels of a type of white blood cell called neutrophils
  • bleeding
  • pneumonia

If experienced, these tend to have a Less Severe expression i

  • constipation
  • fever
  • low energy
  • a skin rash
  • fluid retention in the legs, feet, arms or hands
  • decreased appetite
  • trouble breathing
  • nausea
  • vomiting
  • diarrhea
  • bruising
  • intense abdominal pain
  • pain in the muscles or bones

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • high blood pressure
  • atrial fibrillation
  • atrial flutter
  • bleeding of the stomach or intestines

If experienced, these tend to have a Less Severe expression i

  • dehydration
  • blurred vision
  • a decrease in sharpness of vision called reduced visual acuity
  • inflammation of the tissue lining the sinuses
  • stomatitis, a condition with painful swelling and sores inside the mouth
  • indigestion
  • joint pain
  • muscle spasm
  • dizziness
  • difficulty sleeping
  • small reddish-purplish pin-point sized spots on skin
  • headache
  • nosebleed
  • cough
  • generalized weakness
  • anxious feelings

RARE side effects

If experienced, these tend to have a Severe expression i

  • pneumonia with a fungus called Pneumocystis jirovecii
  • ventricular arrhythmias, a type of abnormal heart rhythm
  • subdural intracranial hemorrhage
  • bleeding within the skull
  • a stroke
  • hardening of the liver
  • liver failure
  • kidney failure
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • Sweet's disease
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • lung tissue problem
  • reactivation of hepatitis B infection
  • progressive multifocal leukoencephalopathy, a type of brain infection
  • an inflammatory condition of fat under the skin with red patches and lumps called panniculitis
  • cancer of the squamous cells in the skin
  • tumor lysis syndrome

If experienced, these tend to have a Less Severe expression i

  • a condition with loosening of the nails from the nailbed called onycholysis

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.