Abatacept/Tumor Necrosis Factor (TNF) Blocking Agents Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of these medicines affect your immune system.

What might happen:

When these medicines are used together, your risk of developing infections, including serious infections, may increase.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want to change your medicine. Let your doctor know right away if you develop any signs of infection, including infections that are only in one place in your body (such as a open sore or cut) or in your whole body (such as the flu), of if you feel sick.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Orencia (abatacept) US prescribing information. Bristol-Myers Squibb Company March 30, 2017.
  • 2.Humira (adalimumab) US prescribing information. Abbott Laboratories December, 2018.
  • 3.Cimzia (certolizumab pegol) US prescribing information. UCB, Inc. February, 2019.
  • 4.Simponi (golimumab) US prescribing information. Centocor Ortho Biotech Inc. March, 2018.
  • 5.Remicade (infliximab) US prescribing information. Janssen Biotech, Inc. June, 2018.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.