Dolutegravir/Etravirine; Efavirenz; Nevirapine Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Etravirine, efavirenz, and nevirapine may speed up how quickly your body processes dolutegravir.

What might happen:

The blood levels of your dolutegravir may be decreased, which will decrease its effectiveness.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have a history of resistance to any HIV medicine. Your doctor may need to change the dose of your dolutegravir, change the protease inhibitor you are taking, or change your NNRTI.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Tivicay (dolutegravir) US prescribing information. GlaxoSmithKline June, 2016.
  • 2.Triumeq (abacavir-dolutegravir-lamivudine) US prescribing information. Viiv Healthcare April 21, 2016.
  • 3.Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Available at http://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultandAdolescentGL.pdf . Accessed July 27, 2016..