Siltuximab is used to treat a certain rare illness (multicentric Castleman's disease - MCD) if you do not have HIV or herpes infections. Siltuximab blocks a certain natural substance that affects the immune system.Siltuximab can improve the symptoms of MCD including lumps under the skin, fever, weakness or tiredness, or night sweats.

How to use

Read the Patient Information Leaflet if available from your pharmacist before you start using siltuximab and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

This medication is given by a health care professional. It is given slowly into a vein as directed by your doctor, usually over 1 hour every 3 weeks. The dosage is based on your weight, medical condition, and response to treatment.

Siltuximab may cause side effects (such as trouble breathing, chest pain/discomfort, pounding heartbeat, wheezing, dizziness, back pain, flushing, nausea, vomiting, swelling of the lips, or rash) while it is being given. Your doctor may decide to temporarily stop or slow down the medication infusion if this happens during your treatment. Tell your healthcare professional right away if you have any of these symptoms. Your doctor may direct you to take other medications (such as antihistamines, drugs for fever, or corticosteroids such as prednisone) to treat your reaction and before your next treatment(s) to prevent these reactions from happening again. If the reaction is severe, your doctor may stop any further treatment with siltuximab.

Use this medication regularly to get the most benefit from it. To help you remember, use it on the same day every 3 weeks.

Tell your doctor if your condition gets worse.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.