Oral Contraceptives/Exenatide; Lixisenatide Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Exenatide and lixisenatide slow down your digestive tract, which may decrease the amount of contraceptive you absorb.

What might happen:

The amount of contraceptive in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. If you are taking exenatide twice daily, you should time your medicines so that you take your oral contraceptive 1 hour before exenatide. Ask your healthcare professional about using oral contraceptives with weekly doses of exenatide. If you are taking lixisenatide, take your oral contraceptive 1 hour before or 11 hours after lixisenatide. If you have any questions about how to take your medicines, ask your pharmacist.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Byetta (exenatide) US prescribing information. AstraZeneca Pharmaceuticals LP February 25, 2015.
  • 2.Adlyxin (lixisenatide) US prescribing information. Sanofi-Aventis U.S. LLC July 27, 2016.
  • 3.Bydureon (exenatide) US prescribing information. AstraZeneca Pharmaceuticals LP October, 2017.
  • 4.Kothare PA, Seger ME, Northrup J, Mace K, Mitchell MI, Linnebjerg H. Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial. BMC Clin Pharmacol 2012;12:8.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.