Who should not take Contrave?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • spread of cancer to the brain
  • tumor of the brain or spinal cord
  • low blood sugar
  • symptoms from alcohol withdrawal
  • symptoms from stopping treatment with opioid drugs
  • manic-depression
  • mood changes
  • psychotic disorder
  • suicidal thoughts
  • alcohol use disorder
  • dependence on opioid-type drugs
  • anorexia nervosa
  • bulimia
  • a low seizure threshold
  • closed angle glaucoma
  • high blood pressure
  • a heart attack
  • a stroke
  • severe liver disease
  • malformed blood vessels
  • seizures
  • weight loss
  • pregnancy
  • seizure caused by sudden withdrawal of benzodiazepine
  • stimulant drug dependence
  • sedative drug dependence
  • opioid use last 4 hours in narcotic addicted patient
  • chronic kidney disease stage 3A (moderate)
  • chronic kidney disease stage 3B (moderate)
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)
  • kidney disease with likely reduction in kidney function

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.