PD-1 and PD-L1 Blocking Antibodies/Thalidomide Analogues Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

It is unknown what increases this risk.

What might happen:

You may be at a higher risk for blood clots in your arteries, veins and lungs, heart attack, and stroke when taking dexamethasone, lenalidomide or thalidomide or pomalidomide, and your cancer drug.

What you should do about this interaction:

If you experience shortness of breath, chest pain, or arm or leg swelling, contact your doctor immediately.If you experience chest pain, pain in your arms, neck, jaw or back, feeling sweaty, shortness of breath, or vomiting, contact your doctor immediately.If you experience sudden numbness of weakness, especially on one side of the body, headache or confusion, or problems with vision, speech, or balance, contact your doctor immediately.Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Pomalyst (pomalidomide) US prescribing information. Celgene Corporation March, 2018.
  • 2.Thalomid (thalidomide) US prescribing information. Celgene Corporation December, 2017.
  • 3.Revlimid (lenalidomide) US prescribing information. Celgene Corporation May 2019.
  • 4.Keytruda (pembrolizumab) injection US prescribing information. Merck Sharp & Dohme Corp. April, 2020.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.