COTELLIC Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • bleeding
  • abnormal liver function tests
  • a high alanine transaminase level
  • a high aspartate transaminase level

If experienced, these tend to have a Less Severe expression i

  • increased sensitivity of the skin to the sun
  • fever
  • nausea
  • vomiting
  • diarrhea

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • squamous cell carcinoma
  • low amount of calcium in the blood
  • high levels of potassium in the blood
  • low amount of potassium in the blood
  • anemia
  • detachment of the retina of the eye
  • a disorder of the retina of the eye
  • vision loss
  • cardiomyopathy, a disease of the heart muscle
  • inflammation of the liver called hepatitis
  • a skin rash
  • high amount of bilirubin in the blood
  • basal cell carcinoma of the skin
  • a type of slow growing skin cancer called a keratoacanthoma

If experienced, these tend to have a Less Severe expression i

  • stomatitis, a condition with painful swelling and sores inside the mouth
  • chills

RARE side effects

If experienced, these tend to have a Severe expression i

  • a blockage of blood vessels in the retina of the eye
  • a type of inflammation of the lung called interstitial pneumonitis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • a condition with muscle tissue breakdown called rhabdomyolysis
  • bleeding from the lungs
  • a second occurrence of melanoma

If experienced, these tend to have a Less Severe expression i

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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.