Atazanavir-Cobicistat/Contraceptives Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, you may process your birth control pills differently.

What might happen:

The effects of your birth control pills may decrease and cause breakthrough bleeding, spotting, or pregnancy.If you are taking atazanavir, you may notice an increase in acne and your cholesterol levels may increase.

What you should do about this interaction:

Talk to your healthcare professional (e.g. doctor or pharmacist) as soon as possible about using a different or additional form of birth control. Contact your doctor if you experience breakthrough bleeding, spotting, or pregnancy.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Evotaz (atazanavir and cobicistat) US prescribing information. Bristol-Myers-Squibb Company March, 2018.
  • 2.Tybost (cobicistat) US prescribing information. Gilead Sciences, Inc. October, 2019.
  • 3.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company March, 2018.
  • 4.Centers for Disease Control and Prevention. U.S. Medical Eligibility Criteria for Contraceptive Use, 2016. MMWR Recomm Rep. Available at: https://www.cdc.gov/mmwr/volumes/65/rr/pdfs/rr6503.pdf July 29, 2016; 65(3):.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.