Elbasvir-Grazoprevir/Rifampin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Rifampin can increase and decrease elbasvir-grazoprevir levels, depending on how which drug you started taking first.

What might happen:

If you are taking elbasvir-grazoprevir and start rifampin, the amount of grazoprevir in your blood may increase for a few days and cause liver problems. After a few days, the amount of elbasvir-grazoprevir in your blood may decrease and it may not work as well.If you are taking rifampin or recently stopped taking rifampin and start taking elbasvir-grazoprevir, the amount of elbasvir-grazoprevir in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together or if you recently stopped taking rifampin. Your doctor may want to check your liver, how your elbasvir-grazoprevir is working, and/or the amount of elbasvir-grazoprevir in your blood. Your doctor may want to change your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Zepatier (elbasvir-grazoprevir) Canadian product monograph. Merck Canada Inc. January 19, 2016.
  • 2.Zepatier (elbasvir-grazoprevir) US prescribing information. Merck & Co., Inc. June, 2018.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.