CABOMETYX Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • low amount of phosphate in the blood
  • low amount of calcium in the blood
  • decreased blood platelets
  • low levels of a type of white blood cell called neutrophils
  • a decreased number of lymphocytes in the blood
  • high amount of bilirubin in the blood
  • erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet
  • abnormal liver function tests
  • a high alanine transaminase level
  • a high aspartate transaminase level
  • If experienced, these tend to have a Less Severe expression i

  • stomatitis, a condition with painful swelling and sores inside the mouth
  • constipation
  • hair discoloration
  • dizziness
  • low energy
  • taste impairment
  • decreased appetite
  • weight loss
  • headache
  • a change in voice
  • nausea
  • vomiting
  • diarrhea
  • generalized weakness
  • intense abdominal pain
  • INFREQUENT side effects

    If experienced, these tend to have a Severe expression i

  • a condition with low thyroid hormone levels
  • low amount of sodium in the blood
  • low amount of potassium in the blood
  • a blood clot in an artery
  • blood clot formation in vein
  • bleeding
  • pneumonia
  • an abnormal connection between the esophagus and windpipe
  • a gastrointestinal tract fistula
  • bleeding of the stomach or intestines
  • an abscess
  • coughing up of blood
  • impaired wound healing
  • a rupture in the wall of the stomach or intestine
  • portions of the jaw bone to die from lack of blood circulation
  • If experienced, these tend to have a Less Severe expression i

  • a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
  • hemorrhoids
  • indigestion
  • erythema or redness of skin or mucous membrane
  • hair loss
  • inflammation of a hair follicle
  • dry skin
  • joint pain
  • muscle spasm
  • a skin rash
  • difficulty swallowing
  • elevation of proteins in the urine
  • a feeling of pins and needles on skin
  • chest pains unrelated to heart problems
  • anxious feelings
  • RARE side effects

    If experienced, these tend to have a Severe expression i

  • extremely high blood pressure
  • a stroke
  • a localized weakening and ballooning in an artery wall called an arterial aneurysm
  • nephrotic syndrome, a type of kidney disorder
  • inflammation of the liver with stoppage of bile flow
  • pancreatitis
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • dissection of artery
  • aneurysm of aorta
  • If experienced, these tend to have a Less Severe expression i

  • thickening of the outer horny layer of the skin
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.