KYMRIAH Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • an infection due to a virus
  • an infection
  • decreased blood platelets
  • low levels of a type of white blood cell called neutrophils
  • a type of brain function problem called encephalopathy
  • decreased oxygen in the tissues or blood
  • a type of immune system problem called hypogammaglobulinemia
  • cytokine release syndrome, a sudden activation of the immune system
  • fast heartbeat

If experienced, these tend to have a Less Severe expression i

  • delirium
  • fever
  • low energy
  • decreased appetite
  • headache
  • nausea
  • vomiting
  • diarrhea

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • a bacterial infection
  • an infection due to a fungus
  • a type of blood disorder with a decrease in all types of blood cells called pancytopenia
  • high blood pressure
  • abnormal heart rhythm
  • low blood pressure
  • bleeding
  • escape of fluid into the lungs
  • fluid in the lungs
  • acute respiratory distress syndrome, a type of lung disorder
  • decreased kidney function
  • seizures
  • rapid breathing
  • hemophagocytic lymphohistiocytosis, a condition where the body makes too many activated immune cells
  • tumor lysis syndrome

If experienced, these tend to have a Less Severe expression i

  • water retention
  • confusion
  • agitation
  • a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
  • a change in vision
  • stuffy nose
  • constipation
  • joint pain
  • backache
  • muscle pain
  • decreased alertness or consciousness
  • dizziness
  • a sleep disorder
  • pain
  • chills
  • muscle tremors
  • loss of muscle coordination
  • fluid retention in the legs, feet, arms or hands
  • puffy face from water retention
  • aphasia, a loss of the ability to speak and understand language
  • cough
  • intense abdominal pain
  • pain in the oropharynx
  • anxious feelings

RARE side effects

If experienced, these tend to have a Severe expression i

  • a type of blood clotting disorder called disseminated intravascular coagulation
  • complete stoppage of the heart
  • bleeding within the skull
  • capillary leak syndrome, a condition where fluid leaks out of small blood vessels
  • reactivation of hepatitis B infection
  • spread of malignant cancer to the bone marrow
  • multiple organ failure

If experienced, these tend to have a Less Severe expression i

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    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.