Does SYMFI Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • LAMIVUDINE/ZALCITABINE
  • SELECTED NEPHROTOXIC AGENTS/CIDOFOVIR
  • EFAVIRENZ/ST. JOHN'S WORT
  • SELECTED NEPHROTOXIC AGENTS/BACITRACIN
  • STRONG & MODERATE CYP2C19 INHIBITORS/MAVACAMTEN
  • STRONG AND MODERATE CYP3A4 INDUCERS/LONAFARNIB
  • EFAVIRENZ; NEVIRAPINE/ASUNAPREVIR
  • STRONG & MOD 2C19 INHIB THAT PROLONG QT/CILOSTAZOL (> 50 MG)
  • EFAVIRENZ; NEVIRAPINE/ELVITEGRAVIR
  • STRONG CYP3A4 INDUCERS/ELBASVIR-GRAZOPREVIR
  • EFAVIRENZ/PARITAPREVIR-RITONAVIR
  • PROTEASE INHIBITORS & NNRTIS/COBICISTAT-ELVITEGRAVIR
  • TENOFOVIR/ADEFOVIR
  • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SELECTED PROTEASE INHIBITORS AND NNRTIS/GARLIC
  • EFAVIRENZ/CARBAMAZEPINE
  • SELECTED NEPHROTOXIC AGENTS/FOSCARNET
  • DEOXYCYTIDINE KINASE SUBSTRATES/CLADRIBINE
  • SELECTED NEPHROTOXIC AGENTS/INOTERSEN
  • EFAVIRENZ/PHENYTOIN
  • STR OR MOD 3A4 INDUC PROL QT/VONOPRAZAN-CLARITHROMYCIN-AMOX
  • STRONG OR MODERATE CYP3A4 INDUCERS/VONOPRAZAN
  • STRONG OR MODERATE CYP3A4 INDUCERS/GANAXOLONE
  • MODERATE CYP3A4 INDUCERS THAT PROLONG QT/PACRITINIB
  • POSSIBLE QT PROLONGING AGENTS/LEVOKETOCONAZOLE
  • MODERATE CYP3A4 INDUCERS/DUVELISIB
  • STRONG OR MODERATE CYP3A4 INDUCERS/AVACOPAN
  • STRONG OR MODERATE 3A4 INDUCERS THAT PROLONG QT/MOBOCERTINIB
  • STRONG & MODERATE CYP3A4 INDUCERS THAT PROLONG QT/SIPONIMOD
  • STRONG & MODERATE 3A4 INDUCERS THAT PROLONG QT/FEXINIDAZOLE
  • STRONG AND MODERATE CYP3A4 INDUCERS/FINERENONE
  • MODERATE CYP3A4 AND P-GP INDUCERS/GLECAPREVIR-PIBRENTASVIR
  • MYELOSUPPRESSIVES; IMMUNOMODULATORS/SODIUM IODIDE I 131
  • MODERATE CYP3A4 INDUCERS/RIPRETINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/IBREXAFUNGERP
  • STRONG AND MODERATE CYP3A4 INDUCERS/INFIGRATINIB
  • STRONG AND MOD CYP3A4 INDUCERS THAT PROLONG QT/PIMAVANSERIN
  • STRONG & MOD CYP3A4 INDUCERS THAT PROLONG QT/BEDAQUILINE
  • STRONG AND MOD CYP3A4 INDUCERS THAT PROLONG QT/SELPERCATINIB
  • STRONG OR MODERATE CYP3A4 INDUCERS THAT PROLONG QT/LEFAMULIN
  • STRONG AND MOD CYP3A4 INDUCERS THAT PROLONG QT/ENTRECTINIB
  • STRONG AND MOD CYP3A4 INDUCERS THAT PROLONG QT/GLASDEGIB
  • STRONG AND MOD CYP3A4 INDUCERS THAT PROLONG QT/ENCORAFENIB
  • MODERATE CYP3A4 INDUCERS THAT PROLONG QT/CRIZOTINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/VOCLOSPORIN
  • MODERATE CYP3A4 INDUCERS/IDELALISIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/LURBINECTEDIN
  • STRONG AND MODERATE CYP3A4 INDUCERS/CAPMATINIB
  • UGT1A1 INDUCERS/SACITUZUMAB GOVITECAN
  • STRONG AND MODERATE CYP3A4 INDUCERS/PEMIGATINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/SELUMETINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/RIMEGEPANT
  • STRONG OR MODERATE CYP3A4 INDUCERS/TAZEMETOSTAT
  • MODERATE CYP3A4 INDUCERS/IBRUTINIB
  • STRONG OR MODERATE CYP3A4 INDUCERS/AVAPRITINIB
  • CYP3A4 INDUCERS/LUMATEPERONE
  • STRONG OR MODERATE CYP3A4 INDUCERS/DARIDOREXANT; LEMBOREXANT
  • SELECTED STRONG OR MODERATE CYP3A4 INDUCERS/VOXELOTOR
  • STRONG OR MODERATE CYP3A4 INDUCERS/ZANUBRUTINIB
  • P-GLYCOPROTEIN (P-GP) OR UGT INDUCERS/LETERMOVIR
  • POSSIBLE QT PROLONGING AGENTS/HYDROXYCHLOROQUINE
  • MODERATE CYP3A4 INDUCERS/FEDRATINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/PRETOMANID
  • P-GP AND MODERATE CYP3A4 INDUCERS/DAROLUTAMIDE
  • SELECTED MODERATE CYP2C9 OR CYP3A4 INDUCERS/ERDAFITINIB
  • MODERATE CYP3A4 INDUCERS/BRIGATINIB
  • MODERATE CYP3A4 INDUCERS/LORLATINIB
  • EFAVIRENZ;ETRAVIRINE;NEVIRAPINE/DORAVIRINE
  • MODERATE CYP3A4 INDUCERS/ABEMACICLIB
  • LAMIVUDINE/SORBITOL
  • STRONG AND MODERATE CYP3A4 INDUCERS/NERATINIB
  • P-GLYCOPROTEIN (P-GP) INDUCERS/ETOPOSIDE
  • MODERATE CYP3A4 INDUCERS/VENETOCLAX
  • SELECTED ANTIRETROVIRALS/ORLISTAT
  • TENOFOVIR DISOPROXIL/COBICISTAT
  • EFAVIRENZ/ATOVAQUONE; PROGUANIL
  • EFAVIRENZ;ETRAVIRINE;NEVIRAPINE/COBICISTAT-BOOSTED DARUNAVIR
  • EFAVIRENZ/ARTEMETHER; LUMEFANTRINE
  • STRONG & MODERATE CYP3A4 INDUCERS/GUANFACINE
  • ETRAVIRINE; EFAVIRENZ; NEVIRAPINE/DOLUTEGRAVIR
  • MODERATE CYP3A4 INDUCERS/BOSUTINIB
  • UGT INDUCERS/CANAGLIFLOZIN
  • EFAVIRENZ; ETRAVIRINE;NEVIRAPINE/SELECTED HEPATITIS C AGENTS
  • STRONG & MODERATE CYP3A4 INDUCERS/SELECTED ANTINEOPLASTICS
  • P-GP & STRONG 3A4 INDUCERS;EFAVIRENZ;PB/APIXABAN;RIVAROXABAN
  • STRONG P-GP OR CYP3A4 INDUCER/LINAGLIPTIN
  • P-GLYCOPROTEIN (P-GP) INDUCERS/DABIGATRAN
  • STRONG UGT INDUCERS/DEFERASIROX
  • EFAVIRENZ/ATAZANAVIR
  • STRONG CYP3A4 INDUCERS/MARAVIROC
  • EFAVIRENZ/ITRACONAZOLE; KETOCONAZOLE; POSACONAZOLE
  • SELECTED NEPHROTOXIC AGENTS/COLISTIMETHATE
  • EFAVIRENZ/VORICONAZOLE
  • EFAVIRENZ/FOSAMPRENAVIR; SAQUINAVIR
  • EFAVIRENZ/INDINAVIR
  • EFAVIRENZ; NEVIRAPINE/HORMONAL CONTRACEPTIVE AGENTS
  • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • TENOFOVIR/SELECTED NEPHROTOXIC AGENTS
  • TENOFOVIR/TELAPREVIR
  • EFAVIRENZ/QT PROLONGING AGENTS
  • SELECTED NEPHROTOXIC AGENTS/IMMUNE GLOBULIN IV (IGIV)
  • SENSITIVE CYP2B6 SUBSTRATES THAT PROLONG QT/MIDOSTAURIN
  • SELECTED SENSITIVE CYP2B6 SUBSTRATES/LEMBOREXANT
  • MODERATE AND WEAK CYP3A4 INDUCERS THAT PROLONG QT/TACROLIMUS
  • QT PROLONGING AGENTS/SAVOLITINIB
  • QT PROLONGING AGENTS/TRICLABENDAZOLE
  • POSSIBLE QT PROLONGING AGENTS/PANOBINOSTAT
  • STRONG AND MODERATE CYP3A4 INDUCERS/ATOGEPANT
  • QT PROLONGING AGENTS/OZANIMOD
  • QT PROLONGING AGENTS/PONESIMOD
  • QT PROLONGING AGENTS/GALANTAMINE
  • SLT 2C19&3A4 INDUCER THAT PROLONG QT/CITALOPRAM;ESCITALOPRAM
  • SELECTED P-GP INDUCERS/BEROTRALSTAT
  • STRONG UGT INDUCERS; NEVIRAPINE/ARTESUNATE
  • QT PROLONGING AGENTS/OSILODROSTAT
  • QT PROLONGING AGENTS/AMISULPRIDE
  • MODERATE CYP3A4 INDUCERS/ROLAPITANT
  • MODERATE AND WEAK CYP3A4 INDUCERS/UBROGEPANT
  • SELECTED UGT AND STRONG CYP3A4 INDUCERS/OXCARBAZEPINE
  • STRONG CYP2C19 AND CYP3A4 INDUCERS/LANSOPRAZOLE
  • STRONG AND MODERATE CYP3A4 INDUCERS/PERAMPANEL
  • POSSIBLE QT PROLONGING AGENTS/RIBOCICLIB
  • MODERATE CYP3A4 INDUCERS/DACLATASVIR
  • SELECTED MODERATE-WEAK CYP3A4 INDUCERS/EXEMESTANE
  • P-GLYCOPROTEIN (P-GP) INDUCERS; PHENOBARBITAL/AFATINIB
  • QT PROLONGING AGENTS/FINGOLIMOD
  • NNRTIS/CLARITHROMYCIN
  • EFAVIRENZ; NEVIRAPINE/LEVOMETHADONE; METHADONE
  • TENOFOVIR DISOPROXIL/ATAZANAVIR
  • EFAVIRENZ/RIFABUTIN
  • TENOFOVIR/DIDANOSINE
  • EFAVIRENZ; NEVIRAPINE/CASPOFUNGIN
  • EFAVIRENZ; NEVIRAPINE/LOPINAVIR
  • STRONG & MOD 2C19 INHIB THAT PROLONG QT/CILOSTAZOL (<=50MG)
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.