Sirolimus Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • low amount of potassium in the blood
  • anemia
  • decreased blood platelets
  • high blood pressure
  • decreased kidney function
  • If experienced, these tend to have a Less Severe expression i

  • high amount of triglyceride in the blood
  • a common cold
  • constipation
  • acne
  • joint pain
  • muscle pain
  • dizziness
  • fever
  • pain
  • visible water retention
  • headache
  • nausea
  • diarrhea
  • intense abdominal pain
  • INFREQUENT side effects

    If experienced, these tend to have a Severe expression i

  • hemolytic uremic syndrome, a condition that affects the kidney and the blood
  • low levels of white blood cells
  • thrombotic thrombocytopenic purpura, a type of blood disorder
  • lymphocele, a cyst containing lymph fluid
  • pyelonephritis, infection and inflammation of the kidney and renal pelvis
  • problems with wound healing after a surgery
  • If experienced, these tend to have a Less Severe expression i

  • stomatitis, a condition with painful swelling and sores inside the mouth
  • an ovarian cyst
  • a problem with menstrual periods
  • nosebleed
  • osteonecrosis, the death of bone tissue due to a lack of blood supply
  • RARE side effects

    If experienced, these tend to have a Severe expression i

  • diarrhea from an infection with Clostridium difficile bacteria
  • an infection by Mycobacteria
  • shingles
  • a herpes simplex infection
  • mononucleosis, the kissing disease
  • an unusual viral infection called cytomegalovirus infection
  • an infection due to a virus
  • pneumonia with a fungus called Pneumocystis jirovecii
  • an infection
  • malignant melanoma, a type of skin cancer
  • squamous cell carcinoma
  • diabetes
  • low amount of phosphate in the blood
  • high levels of potassium in the blood
  • a type of blood disorder with a decrease in all types of blood cells called pancytopenia
  • low levels of a type of white blood cell called neutrophils
  • a clot in the lung
  • pulmonary hypertension
  • fluid in the covering of the heart or pericardium
  • obstruction of a blood vessel by a blood clot
  • allergic reaction causing inflammation of blood vessels
  • blood clot in a deep vein of the extremities
  • a type of lung condition called bronchiolitis obliterans
  • pneumonia
  • escape of fluid into the lungs
  • a type of inflammation of the lung called interstitial pneumonitis
  • a condition where there is formation of fibrous tissue in the lung called pulmonary fibrosis
  • a hernia which protrudes into the abdominal wall
  • liver tissue death
  • inflammation of the liver called hepatitis
  • nephrotic syndrome, a type of kidney disorder
  • skin rash with sloughing
  • trouble breathing
  • chest pain
  • ascites
  • impaired wound healing
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • a hypersensitivity reaction to a drug
  • disorder of lymphoid tissue after transplant
  • malignant lymphoma
  • a blood clot in the liver after a liver transplant
  • a bronchial anastomotic dehiscence where the transplanted lung surgical connection comes apart
  • bleeding from the lungs
  • lung tissue problem
  • pancreatitis
  • progressive multifocal leukoencephalopathy, a type of brain infection
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • focal segmental glomerulosclerosis, a type of kidney condition that can eventually lead to failure
  • kidney problems due to BK polyomavirus
  • sepsis
  • a high alanine transaminase level
  • a high aspartate transaminase level
  • If experienced, these tend to have a Less Severe expression i

  • low sperm count
  • basal cell carcinoma of the skin
  • lymphedema, or swelling due to blockage of lymph nodes
  • absence of sperm in semen
  • a type of skin cancer called Merkel cell carcinoma
  • fast heartbeat
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.