Warnings:

Pexidartinib may rarely cause serious (possibly fatal) liver disease. Careful monitoring by your doctor may decrease your risk. Your doctor will check liver tests before you start taking this medication and regularly during treatment (usually every week for the first 8 weeks, then every 2 weeks for one month, then every 3 months). Based on your results, your doctor may check lab tests more often. Tell your doctor right away if you develop symptoms such as nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

For patients to receive this medication, all doctors, pharmacists, and patients must agree to, understand, and carefully follow the requirements of the Turalio REMS Program. These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.

Uses

This medication is used to treat a certain type of tumor (tenosynovial giant cell tumor) that is not likely to improve with surgery. Pexidartinib belongs to a class of drugs known as kinase inhibitors. It works by slowing or stopping the growth of certain tumor cells.

How to use Pexidartinib 200 Mg Capsule

Read the Medication Guide provided by your pharmacist before you start taking pexidartinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually twice daily on an empty stomach, at least 1 hour before or 2 hours after food. Swallow the capsules whole. Do not open, break, or chew the capsules.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

If you vomit after taking a dose, do not take another dose. Take your next dose at the regular time.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine.

Avoid certain drugs that reduce stomach acid/heartburn (proton pump inhibitors-PPIs such as lansoprazole, omeprazole) during treatment with pexidartinib. If you are taking an antacid, take it 2 hours before or after taking this medication. If you are taking certain other drugs that reduce stomach acid/heartburn (H2 blockers such as famotidine, ranitidine), take it at least 10 hours before or 2 hours after pexidartinib.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.