Selected Nephrotoxic Agents/Cidofovir Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Adefovir, intravenous aminoglycosides, amphotericin B, capreomycin, cisplatin, gallium nitrate, foscarnet, high-dose methotrexate, intravenous pentamidine, tenofovir, vancomycin, and non-steroidal anti-inflammatory agents may result in renal toxicity and cidofovir may all damage your kidneys.

What might happen:

Taking these medicines together may increase the risk of damage to your kidneys.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are using these medicines together. Your doctor may want you to stop using medicines such as adefovir, intravenous aminoglycosides, amphotericin B, capreomycin, cisplatin, gallium nitrate, foscarnet, high-dose methotrexate, intravenous pentamidine, tenofovir, vancomycin, and non-steroidal anti-inflammatory agents. Be sure to keep all laboratory appointments and let your doctor know if you notice a change in amount of urine you are making.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Vistide (cidofovir) Australian prescribing information. Pfizer Australia Pty Ltd. July 28, 2004.
  • 2.Vistide (cidofovir) UK summary of product characteristics. Gilead Sciences Ltd January, 2011.
  • 3.Vistide (cidofovir) US prescribing information. Gilead Sciences, Inc. September, 2000.