Zonisamide Side Effects by Likelihood and Severity

COMMON side effects


If experienced, these tend to have a Severe expression

  • Loss Of Muscle Coordination

If experienced, these tend to have a Less Severe expression

  • Agitation
  • Decreased Appetite
  • Dizziness
  • Drowsiness
  • Headache
  • Nausea

INFREQUENT side effects


If experienced, these tend to have a Severe expression

  • A Form Of Schizophrenia Called Simple Schizophrenia
  • A Skin Rash
  • Bruising Under The Skin
  • Confusion
  • Depression
  • Kidney Stones

If experienced, these tend to have a Less Severe expression

  • A Stuffy And Runny Nose
  • A Type Of Speech Disorder Called Dysarthria
  • Anxious Feelings
  • Constipation
  • Diarrhea
  • Difficulty Concentrating
  • Difficulty Sleeping
  • Double Vision
  • Dry Mouth
  • Flu-Like Symptoms
  • Indigestion
  • Intense Abdominal Pain
  • Low Energy
  • Memory Loss
  • Mental Status Changes
  • Nervousness
  • Numbness And Tingling
  • Nystagmus, A Condition With Involuntary Eye Movements
  • Taste Impairment
  • Vomiting
  • Weight Loss

RARE side effects


If experienced, these tend to have a Severe expression

  • A Condition With Muscle Tissue Breakdown Called Rhabdomyolysis
  • A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome
  • A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis
  • A Type Of Abnormal Movement Disorder Called Dyskinesia
  • A Type Of Brain Function Problem Called Encephalopathy
  • A Type Of Bumpy Skin Rash Called A Maculopapular Rash
  • A Type Of Significant Allergic Skin Reaction Called DRESS Syndrome
  • Abnormal Heart Electrical Signals
  • Abnormal Liver Function Tests
  • An Accidental Injury
  • Anemia
  • Apnea, A Breathing Interruption
  • Blood Coming From Anus
  • Coughing Up Of Blood
  • Decreased Blood Platelets
  • Decreased Kidney Function
  • Decreased Sweating
  • Dehydration
  • Excess Body Acid
  • Fever
  • Gallstones
  • High Amount Of Ammonium In The Blood
  • Increased Eosinophils In The Blood
  • Inflammation Of The Gallbladder
  • Inflammation Of The Large Intestine
  • Inflammation Of The Lining Of The Stomach And Intestines
  • Liver Tissue Death
  • Low Amount Of Sodium In The Blood
  • Low Blood Counts Due To Bone Marrow Failure
  • Low Levels Of A Type Of White Blood Cell Called Neutrophils
  • Low Levels Of White Blood Cells
  • Mental Problems From Taking The Drug
  • Overgrowth Of Gums Onto Teeth
  • Painful And Involuntary Movement Of The Eyes Called Oculogyric Crisis
  • Pancreatitis
  • Secondary Angle-Closure Glaucoma, A Type Of Eye Disorder
  • Suicidal Thoughts
  • Systemic Lupus Erythematosus, An Autoimmune Disease
  • Trouble Breathing
  • Very Low Levels Of Granulocytes, A Type Of White Blood Cell

If experienced, these tend to have a Less Severe expression

  • A Distorted Sense Of Smell Called Parosmia
  • A Feeling Of General Discomfort Called Malaise
  • A Problem With Menstrual Periods
  • Abnormal Manner Of Walking
  • An Inability To Completely Empty The Bladder
  • An Increased Need To Urinate Often
  • Aphasia, A Loss Of The Ability To Speak And Understand Language
  • Behavioral Problems
  • Chest Pain
  • Cough
  • Difficulty Swallowing
  • Enlarged Breasts
  • Fainting
  • Gas
  • Generalized Weakness
  • Hearing Loss
  • Heart Throbbing Or Pounding
  • Hirsutism, A Condition Of Hair Growth On Parts Of The Body Normally Without Hair
  • Hyperesthesia, An Increased Nerve Sensitivity
  • Increased Creatine Kinase Levels
  • Itching
  • Joint Pain
  • Lazy Eye
  • Leg Cramps
  • Low Blood Sugar
  • Muscle Pain
  • Muscle Weakness
  • Nearsightedness
  • Neck Stiffness
  • Pink Eye
  • Ringing In The Ears
  • Small Reddish-Purplish Pin-Point Sized Spots On Skin
  • Stomatitis, A Condition With Painful Swelling And Sores Inside The Mouth
  • Swollen Lymph Nodes
  • Throat Irritation
  • Thrombophlebitis, An Inflamed Vein Due To A Blood Clot
  • Visible Water Retention

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.