Does PAXLOVID (EUA) Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SELECTED PROTEASE INHIBITORS/AMIODARONE
  • SELECTED PROTEASE INHIBITORS/BEPRIDIL
  • NIRMATRELVIR-RITONAVIR; TIPRANAVIR/FLECAINIDE; PROPAFENONE
  • PROTEASE INHIBITORS/ORAL MIDAZOLAM; TRIAZOLAM
  • RITONAVIR/PROPOXYPHENE
  • SELECTED CYP3A4 INHIBITORS/PIMOZIDE
  • PROTEASE INHIBITORS/ERGOT ALKALOIDS
  • SELECTED PROTEASE INHIBITORS/QUINIDINE
  • PROTEASE INHIBITORS/ASTEMIZOLE; TERFENADINE
  • SELECTED PROTEASE INHIBITORS; COBICISTAT/CYP3A4 INDUCERS
  • STRONG CYP3A4 INHIBITORS/PIMAVANSERIN (> 10 MG)
  • NIRMATRELVIR-RITONAVIR/SLT IMMUNOSUPPRESSANTS;TEMSIROLIMUS
  • STRONG CYP3A4 INHIBITORS/MAVACAMTEN
  • STRONG CYP3A4 INHIBITORS/PACRITINIB
  • SELECTED STRONG CYP3A4 INHIBITORS/CONIVAPTAN
  • STRONG CYP3A4 INHIBITORS/FINERENONE
  • STRONG CYP3A4 INHIBITORS/VOCLOSPORIN
  • UGT1A1 INDUCERS/CABOTEGRAVIR
  • CYP3A4 & UGT1A1 INDUCERS/CABOTEGRAVIR-RILPIVIRINE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LONAFARNIB
  • STRONG CYP3A4 INHIBITORS/LUMATEPERONE (>10.5 MG)
  • STRONG CYP3A4 INHIBITORS/UBROGEPANT
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR;DARUNAVIR/LERCANIDIPINE
  • SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (>50MG)
  • STRONG CYP3A4 INHIBITORS/DAPAGLIFLOZIN-SAXAGLIPTIN-METFORMIN
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ASUNAPREVIR
  • STRONG OR MODERATE CYP3A4 INHIBITORS/LOMITAPIDE
  • OATP1B1-3 INHIBITORS/ELBASVIR-GRAZOPREVIR
  • SELECTED STRONG CYP3A4 INHIBITORS/ISAVUCONAZONIUM
  • STRONG CYP3A4 INHIBITORS/PANOBINOSTAT (> 10 MG)
  • STRONG CYP3A4 INHIBITORS/NALOXEGOL
  • STRONG CYP3A4 INHIBITORS/AVANAFIL
  • 3A4INHIB/DAPOXETINE;LEVOMILNACIPRAN(>80MG);VILAZODONE(>20MG)
  • STRONG OR MODERATE CYP3A4 INHIBITORS/FLIBANSERIN
  • STRONG CYP3A4 INHIBITORS/SLT HIGH STRENGTH ANTIMUSCARINICS
  • SELECTED STRONG CYP3A4 INHIBITORS/DOMPERIDONE; CISAPRIDE
  • STRONG CYP3A4 INHIBITORS; PROTEASE INHIBITORS/TICAGRELOR
  • SELECTED PROTEASE INHIBITORS; COBICISTAT/LURASIDONE
  • HIV PROTEASE INHIBITORS; COBICISTAT/SILDENAFIL (FOR PAH)
  • STRONG CYP3A4 INHIB;ATAZANAV;DARUNAVIR/SAXAGLIPTIN (>2.5 MG)
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR; DARUNAVIR/DRONEDARONE
  • P-GP AND STRONG CYP3A4 INHIBITORS/RIVAROXABAN
  • STRONG CYP3A4 INHIBITORS; PROTEASE INHIBITORS/RANOLAZINE
  • STRONG CYP3A4 INHIBITORS/TOLVAPTAN
  • STRONG CYP3A4 INHIBITORS; PROTEASE INHIBITORS/IVABRADINE
  • PROTEASE INHIBITORS/ALFUZOSIN;SILODOSIN;TAMSULOSIN
  • SELECTED PROTEASE INHIBITORS/VARDENAFIL
  • STRONG CYP3A4 INHIBITORS/EPLERENONE
  • STRONG CYP3A4 INHIBITORS/IRINOTECAN
  • SELECTED PROTEASE INHIBITORS; COBICISTAT/ELETRIPTAN
  • SELECTED CYP3A4 INHIBITORS/LOVASTATIN; SIMVASTATIN
  • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SELECTED PROTEASE INHIBITORS/ALPRAZOLAM
  • SELECTED PROTEASE INHIBITORS/CONTRACEPTIVES
  • SELECTED PROTEASE INHIBITORS AND NNRTIS/GARLIC
  • NIRMATRELVIR-RITONAVIR/RIFAPENTINE
  • SELECTED PROTEASE INHIBITORS/VONOPRAZAN-CLARITHROMYCIN
  • STRONG CYP3A4 INHIBITORS/MITAPIVAT
  • STRONG CYP3A4 INHIBITOR/TOLTERODINE (>1 MG IR OR >2 MG ER)
  • STRONG CYP3A4 INHIBITORS/RIVOCERANIB
  • NIRMATRELVIR-RITONAVIR/RIFABUTIN
  • STRONG CYP3A4 INHIBITORS/DARIDOREXANT
  • STRONG CYP3A4 INHIBITORS/LEVOKETOCONAZOLE
  • STRONG CYP3A4 INHIBITORS/UPADACITINIB (>=30 MG)
  • STRONG CYP3A4 INHIBITORS/RUPATADINE
  • STRONG CYP3A4 INHIBITORS/SURUFATINIB
  • STRONG CYP3A4 INHIBITORS/AVACOPAN
  • STRONG CYP3A4 INHIBITORS/MOBOCERTINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/FEXINIDAZOLE
  • OATP1B1-3 INHIBITORS/BRINCIDOFOVIR
  • STRONG AND MODERATE CYP3A4 INHIBITORS/INFIGRATINIB
  • DUAL STRONG CYP3A4 INHIBITOR & P-GP INHIBITORS/TEPOTINIB
  • P-GLYCOPROTEIN (P-GP) INHIBITORS/RELUGOLIX
  • STRONG CYP3A4 INHIBITORS/TOREMIFENE
  • STRONG CYP3A4 INHIBITORS/SUNITINIB
  • STRONG CYP3A4 INHIBITORS/PAZOPANIB
  • STRONG CYP3A4 INHIBITORS/NILOTINIB
  • STRONG CYP3A4 INHIBITORS/LAPATINIB
  • STRONG CYP3A4 INHIBITORS/DASATINIB
  • STRONG CYP3A4 INHIBITORS/CRIZOTINIB
  • STRONG CYP3A4 INHIBITORS/CERITINIB
  • STRONG CYP3A4 INHIBITORS/VINFLUNINE
  • STRONG CYP3A4 INHIBITORS/VINCRISTINE
  • STRONG CYP3A4 INHIBITORS/VINBLASTINE
  • STRONG CYP3A4 INHIBITORS/TOFACITINIB
  • STRONG CYP3A4 INHIBITORS/SONIDEGIB
  • STRONG CYP3A4 INHIBITORS/RUXOLITINIB
  • STRONG CYP3A4 INHIBITORS/PONATINIB
  • STRONG CYP3A4 INHIBITORS/PALBOCICLIB
  • STRONG CYP3A4 INHIBITORS/PACLITAXEL
  • STRONG CYP3A4 INHIBITORS/OLAPARIB
  • STRONG CYP3A4 INHIBITORS/IXABEPILONE
  • STRONG CYP3A4 INHIBITORS/IDELALISIB
  • STRONG CYP3A4 INHIBITORS/ERLOTINIB
  • STRONG CYP3A4 INHIBITORS/DOXORUBICIN
  • STRONG CYP3A4 INHIBITORS/DOCETAXEL
  • STRONG CYP3A4 INHIBITORS/DABRAFENIB
  • STRONG CYP3A4 INHIBITORS/COBIMETINIB
  • STRONG CYP3A4 INHIBITORS/CABOZANTINIB
  • STRONG CYP3A4 INHIBITORS/CABAZITAXEL
  • STRONG CYP3A4 INHIBITORS/AXITINIB
  • STRONG CYP3A4 INHIBITORS/SUVOREXANT
  • STRONG CYP3A4 AND P-GP INHIBITORS/PRALSETINIB
  • STRONG CYP3A4 INHIBITORS/PLITIDEPSIN
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LURBINECTEDIN
  • STRONG CYP3A4 INHIBITORS/SELPERCATINIB
  • UGT1A1 INDUCERS/SACITUZUMAB GOVITECAN
  • STRONG AND MODERATE CYP3A4 INHIBITORS/PEMIGATINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/SELUMETINIB
  • STRONG CYP3A4 INHIBITORS/RIMEGEPANT
  • STRONG CYP3A4 INHIBITORS/NIMODIPINE
  • STRONG CYP3A4 INHIBITORS/TAZEMETOSTAT
  • STRONG CYP3A4 INHIBITORS/AVAPRITINIB
  • SELECTED CYP3A4 INHIBITORS/FLUTICASONE-SALMETEROL
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LEMBOREXANT
  • P-GLYCOPROTEIN (P-GP) OR UGT INDUCERS/LETERMOVIR
  • STRONG CYP3A4 INHIBITORS/ELEXACAFTOR-TEZACAFTOR-IVACAFTOR
  • STRONG CYP3A4 INHIBITORS/NALDEMEDINE
  • STRONG CYP3A4 INHIBITORS/ISTRADEFYLLINE
  • SELECTED STRONG CYP3A4 INHIBITORS/ORAL LEFAMULIN
  • STRONG CYP3A4 INHIBITORS/FEDRATINIB
  • STRONG CYP3A4 INHIBITORS/ENTRECTINIB
  • STRONG CYP3A4 INHIBITORS/PEXIDARTINIB
  • STRONG CYP3A4 INHIBITORS/BOSUTINIB
  • SELECTED MODERATE CYP2C9 OR CYP3A4 INDUCERS/ERDAFITINIB
  • SELECTED PROTEASE INHIBITORS; COBICISTAT/CLOPIDOGREL
  • SELECTED MODERATE CYP2C9 INDUCERS/SIPONIMOD
  • PROTEASE INHIBITORS/QUETIAPINE
  • STRONG CYP3A4 INHIBITORS/LAROTRECTINIB
  • STRONG CYP3A4 INHIBITORS/GLASDEGIB
  • STRONG CYP3A4 INHIBITORS/LORLATINIB
  • STRONG CYP3A4 INHIBITORS/DUVELISIB
  • STRONG CYP3A4 INHIBITORS/ELAGOLIX
  • SELECTED STRONG CYP3A4 INHIBITORS/IVOSIDENIB
  • STRONG CYP3A4 INHIBITORS/ARIPIPRAZOLE LAUROXIL SUBMICRONIZED
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ENCORAFENIB
  • SELECTED PROTEASE INHIBITORS/SODIUM FUSIDATE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/TEZACAFTOR-IVACAFTOR
  • SELECTED INHIBITORS OF BCRP/CLADRIBINE
  • SELECTED STRONG CYP3A4 INHIBITOR;PROTEASE INHIB/DISOPYRAMIDE
  • STRONG CYP3A4 INHIBITORS/IBRUTINIB
  • STRONG CYP3A4 INHIBITORS/ACALABRUTINIB
  • STRONG CYP3A4 INHIBITORS/ABEMACICLIB
  • STRONG CYP3A4 INHIBITORS/COPANLISIB
  • DARUNAVIR; LOPINAVIR; RITONAVIR/GLECAPREVIR-PIBRENTASVIR
  • STRONG CYP3A4 INHIB;MODERATE 3A4 & P-GP DUAL INHIB/NERATINIB
  • STRONG CYP3A4 INHIBITORS/BRIGATINIB
  • STRONG CYP3A4 INHIBITORS/VALBENAZINE
  • STRONG CYP3A4 INHIBITORS/RIBOCICLIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/DEFLAZACORT
  • SELECTED ANTIRETROVIRALS/ORLISTAT
  • STRONG CYP3A4 INHIBITORS/VENETOCLAX
  • STRONG CYP3A4 INHIBITORS/VEMURAFENIB
  • STRONG CYP3A4 INHIBITORS/TRABECTEDIN
  • STRONG CYP3A4 INHIBITORS/CARIPRAZINE
  • OATP1B1 INHIBITORS/ELUXADOLINE
  • STRONG CYP3A4 INHIB;ATAZANAV;DARUNAVIR/BEDAQUILINE;DELAMANID
  • SLT STRONG CYP3A4 INHIBITOR & SUBSTRATE/LUMACAFTOR-IVACAFTOR
  • RITONAVIR/ISAVUCONAZONIUM
  • STRONG CYP3A4 INHIBITORS/TRASTUZUMAB EMTANSINE
  • STRONG 3A4 INHIBITORS/ESZOPICLONE > 2 MG; ZOPICLONE > 5 MG
  • STRONG CYP3A4 INHIBITORS/DACLATASVIR
  • STRONG & MODERATE CYP3A4 INHIBITORS/ELIGLUSTAT
  • STRONG CYP3A4 INHIBITORS/VORAPAXAR
  • STRONG & MODERATE CYP3A4 INHIBITORS/GUANFACINE
  • STRONG OR MODERATE CYP3A4 INHIBITORS/SIMEPREVIR
  • STRONG CYP3A4 INHIBITORS/MACITENTAN
  • P-GP AND STRONG CYP3A4 INHIBITORS/APIXABAN
  • UGT INDUCERS/CANAGLIFLOZIN
  • STRONG CYP3A4 INHIBITORS/REGORAFENIB
  • STRONG CYP3A4 INHIBITORS; AMPRENAVIR;ATAZANAVIR/MIFEPRISTONE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/IVACAFTOR
  • SELECTED PROTEASE INHIBITORS/QUININE
  • SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/ALISKIREN
  • COBICISTAT; HCV OR HIV PROTEASE INHIBITORS/SALMETEROL
  • STRONG UGT INDUCERS/DEFERASIROX
  • RITONAVIR/ULIPRISTAL
  • PROTEASE INHIBITORS/BOSENTAN
  • P-GLYCOPROTEIN (P-GP) INHIBITORS/TOPOTECAN
  • SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/DABIGATRAN
  • SELECTED PROTEASE INHIBITORS/MARAVIROC
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR/COLCHICINE
  • SELECTED CYP3A4 INHIBITORS/SELECTED OPIOIDS
  • SELECTED CYP3A4 INHIBITORS/TRAZODONE
  • SELECTED CYP3A4 INHIBITORS/SELECTED STEROIDS
  • COBICISTAT; RITONAVIR/VORICONAZOLE
  • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • RITONAVIR/BUPROPION
  • ATAZANAVIR; RITONAVIR/POSACONAZOLE
  • STRONG CYP3A4 INHIBITORS/LUMATEPERONE (<=10.5 MG)
  • RITONAVIR/CANNABIDIOL
  • SELECTED CYP3A4 INHIBITORS/MOMETASONE
  • STRONG CYP3A4 INHIBITORS/GILTERITINIB
  • NIRMATRELVIR-RITONAVIR/SELECTED PROTEASE INHIBITORS
  • NIRMATRELVIR-RITONAVIR/ERYTHROMYCIN
  • NIRMATRELVIR-RITONAVIR/SELECTED CALCIUM CHANNEL BLOCKERS
  • STRONG CYP3A4 INHIBITORS/TOLTERODINE (<=1 MG OR <=2 MG ER)
  • NIRMATRELVIR-RITONAVIR/ATORVASTATIN; ROSUVASTATIN
  • STRONG CYP3A4 INHIBITORS/UPADACITINIB (<30 MG)
  • OATP1B1-3 INHIBITORS/ATOGEPANT
  • STRONG CYP3A4 INHIBITORS/ATOGEPANT
  • STRONG CYP3A4 INHIBITORS/IBREXAFUNGERP
  • SELECTED CYP1A2 INDUCERS/OLANZAPINE-SAMIDORPHAN
  • STRONG CYP3A4 INHIBITORS/REPAGLINIDE
  • PROTEASE INHIBITORS/SELECTED BENZODIAZEPINES
  • STRONG CYP2D6 OR CYP3A4 INHIBITORS/OLICERIDINE
  • STRONG CYP3A4 INHIBITORS/FOSTAMATINIB
  • STRONG UGT INDUCERS; NEVIRAPINE/ARTESUNATE
  • STRONG CYP3A4 INHIBITORS/OSILODROSTAT
  • SELECTED STRONG CYP3A4 INHIBITORS/ROMIDEPSIN
  • STRONG CYP3A4 INHIBITORS/CANNABIDIOL-TETRAHYDROCANNABINOL
  • SELECTED STRONG CYP3A4 INHIBITORS/MEFLOQUINE
  • STRONG CYP3A4 INHIBITORS/ZANUBRUTINIB
  • P-GP AND STRONG CYP3A4 INHIBITORS/DAROLUTAMIDE
  • SELECTED STRONG CYP3A4 INHIBITORS/ILOPERIDONE
  • SELECTED PROTEASE INHIBITORS/LIDOCAINE
  • STRONG CYP3A4 INHIBITORS/BREXPIPRAZOLE
  • SELECTED UGT AND STRONG CYP3A4 INDUCERS/OXCARBAZEPINE
  • LAPATINIB; RITONAVIR/EDOXABAN (<= 30 MG)
  • STRONG CYP3A4 INHIBITORS/CLONAZEPAM
  • SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/BETRIXABAN
  • STRONG CYP3A4 INHIBITORS/MIDOSTAURIN
  • RITONAVIR/THYROID PREPARATIONS
  • SELECTED CYP1A2 INDUCERS/OLANZAPINE
  • STRONG CYP3A4 INHIBITORS/PIMAVANSERIN (<= 10 MG)
  • SELECTED CYP3A4 INHIBITORS/BROMOCRIPTINE; CABERGOLINE
  • SELECTED CYP3A4 INHIBITORS/FELODIPINE
  • LAPATINIB; RITONAVIR/EDOXABAN (> 30 MG)
  • LOPINAVIR; NELFINAVIR; NEVIRAPINE; RITONAVIR/WARFARIN DERIVS
  • P-GP AND SELECTED CYP3A4 INHIBITORS/NINTEDANIB
  • STRONG 3A4 INHIB/LEVOMILNACIPRAN(<=80MG);VILAZODONE(<=20MG)
  • P-GLYCOPROTEIN (P-GP) INHIBITORS/AFATINIB
  • BOCEPREVIR; RITONAVIR; TELAPREVIR/DIGOXIN
  • RITONAVIR/LEVOMETHADONE; METHADONE
  • LOPINAVIR; RITONAVIR/LAMOTRIGINE
  • STRONG CYP3A4 INHIBITORS/PANOBINOSTAT (<= 10 MG)
  • HIV PROTEASE INHIBITORS;COBICISTAT/SILDENAFIL (ED);TADALAFIL
  • STRONG CYP3A4 INHIB;ATAZANAV;DARUNAVIR/SAXAGLIPTIN(<=2.5 MG)
  • SELECTED WEAK CYP2D6 INHIBITORS/TAMOXIFEN
  • CYP3A4; CYP2C8; P-GLYCOPROTEIN (P-GP) INHIBITORS/LOPERAMIDE
  • STRONG CYP3A4 INHIBITORS/BUSPIRONE
  • STRONG CYP3A4 INHIBITORS/ESZOPICLONE; ZOPICLONE; ZOLPIDEM
  • SELECTED CYP3A4 INHIBITORS/ITRACONAZOLE; KETOCONAZOLE
  • STRONG CYP3A4 INHIBITORS/CINACALCET
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR; DARUNAVIR/ARIPIPRAZOLE
  • SELECTED STRONG CYP3A4 INHIBITORS/ARTEMETHER;LUMEFANTRINE
  • SELECTED PROTEASE INHIBITORS/CLARITHROMYCIN
  • STRONG CYP3A4 INHIBITORS/SLT LOW STRENGTH ANTIMUSCARINICS
  • SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (<=50MG)
  • Drug Survey

    Are you currently using Paxlovid (EUA)?

    This survey is being conducted by the WebMD marketing sciences department.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.