Who should not take Glyburide-Metformin HCL?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • infection
  • low blood sugar
  • pituitary hormone deficiency
  • decreased function of the adrenal gland
  • inadequate vitamin B12
  • excess body acid
  • extreme loss of body water
  • alcoholism
  • alcohol intoxication
  • heart attack
  • suddenly serious symptoms of heart failure
  • liver problems
  • fever
  • Shock
  • Severe Vomiting
  • Severe Diarrhea
  • Serious Lack of Oxygen in the Blood
  • Weakened Patient
  • Sepsis
  • chronic kidney disease stage 3B (moderate)
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)
  • kidney disease with likely reduction in kidney function
  • Addison's disease
  • hepatic porphyria
  • hemolytic anemia
  • severe liver disease
  • kidney disease with reduction in kidney function
  • severe renal impairment
  • Body Temperature More Than 101 Degrees F


  • Sulfonylureas
  • Biguanides

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.