What should I Know Regarding Pregnancy, Nursing and Administering Glyburide-Metformin HCL to Children or the Elderly?
If you are PREGNANT
- FDB Only When Necessary: INSUFFICIENT HUMAN DATA AVAILABLE
- Possibly Safe: PROLONGED HYPOGLYCEMIA REPORTED; MFR REC. STOPPING 2 WKS BEFORE DELIVERY
If you are NURSING
- Precaution: NO KNOWN INFANT ADVERSE OUTCOMES; MFR ADVISES CAUTION
- Precaution: LIMITED DATA SUGGEST NEGLIGIBLE AMT EXCRETED W/NO RESULTING INFANT ADV EFFECT
If you are an adult over 60
- management or monitoring precaution: Renal-Substantial renal clearance results in higher risk for severe, prolonged hypoglycemia in the elderly. Use lower initial and maintenance dose or consider other safer hypoglycemic agents. Hepatic- Hepatic insufficiency may increase risk of hypoglycemia.
- management or monitoring precaution: Renal-Increased risk for drug induced metabolic acidosis with increasing age and declining renal function. Metformin is contraindicated in patients with an eGFR below 30 mL/min. Cardiovascular-Heart failure patients may have a higher risk for metabolic acidosis.
Giving Glyburide-Metformin HCL to a child under 12
- management or monitoring precaution: Safety and efficacy in pediatrics not established.
- management or monitoring precaution: Safety and efficacy in pediatrics age < 10 years not established.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.