Lepirudin/Platelet Aggregation Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Lepirudin and platelet aggregation inhibitors decrease your body's ability to make clots. When these two medicines are taken together, the effects of your lepirudin may be increased.

What might happen:

You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these two medicines together. They may already may be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, you may need to check your bleeding times more often. Do not start, stop, or change the dosage of any medicine before checking with them first. Let your doctor know right away if you have any symptoms of bleeding.

  • 1.Refludan (lepirudin (rDNA)) US prescribing information. Berlex Laboratories October, 2002.
  • 2.Cochran K, DeMartini TJ, Lewis BE, O Brien J, Steen LH, Grassman ED, Leya F. Use of lepirudin during percutaneous vascular interventions in patients with heparin-induced thrombocytopenia. J Invasive Cardiol 2003 Nov; 15(11):617-21.