If you are:
Absolute Contraindication: FDA X FOR MIGRAINE PROPHYLAXIS, FDA D FOR EPILEPSY AND MANIA
Precaution: ONE CASE OF THROMBOCYTOPENIA REPORTED, MONITOR INFANT FOR ADVERSE EFFECTS
An adult over 60:
management or monitoring precaution: Hepatic-Elderly may have slower metabolism and protein binding which requires dosage reduction. Monitor closely. Neuro/Psych-Use caution in elderly with a history of recurrent falls. Drug may produce somnolence, ataxia, impaired psychomotor function, syncope, and additional falls. Monitor fluid and nutritional intake and avoid dehydration. Musculoskeletal-Postmarketing reports of fractures, decreased bone mineral density, osteopenia, osteoporosis.
Giving Depakote ER to a child under 12:
Severe Precaution: Increased risk of serious or fatal hepatotoxicity.