Does LOPINAVIR-RITONAVIR Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SELECTED PROTEASE INHIBITORS/BEPRIDIL
  • PROTEASE INHIBITORS/ORAL MIDAZOLAM; TRIAZOLAM
  • RITONAVIR/PROPOXYPHENE
  • SELECTED CYP3A4 INHIBITORS/PIMOZIDE
  • PROTEASE INHIBITORS/ERGOT ALKALOIDS
  • SELECTED CYP3A4 SUBSTRATES/RIFAMPIN
  • PROTEASE INHIBITORS/ASTEMIZOLE; TERFENADINE
  • SELECTED CYP3A4 SUBSTRATES/ST. JOHN'S WORT
  • PROTEASE INHIBITORS/APALUTAMIDE
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/PACRITINIB
  • STR CYP3A4 INHIBITORS THAT PROLONG QT/PANOBINOSTAT (> 10 MG)
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/LEVOKETOCONAZOLE
  • SELECTED STRONG CYP3A4 INHIBITORS/CONIVAPTAN
  • STRONG CYP3A4 INHIBITORS/FINERENONE
  • STRONG CYP3A4 INHIBITORS/VOCLOSPORIN
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/RANOLAZINE
  • UGT1A1 INDUCERS/CABOTEGRAVIR
  • CYP3A4 & UGT1A1 INDUCERS/CABOTEGRAVIR-RILPIVIRINE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LONAFARNIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/IVABRADINE
  • STRONG CYP3A4 INHIBITORS/UBROGEPANT
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR;DARUNAVIR/LERCANIDIPINE
  • RITONAVIR/NERATINIB
  • SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (>50MG)
  • STRONG CYP3A4 INHIBITORS/DAPAGLIFLOZIN-SAXAGLIPTIN-METFORMIN
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ASUNAPREVIR
  • STRONG OR MODERATE CYP3A4 INHIBITORS/LOMITAPIDE
  • OATP1B1-3 INHIBITORS/ELBASVIR-GRAZOPREVIR
  • STRONG CYP3A4 INHIBITORS/NALOXEGOL
  • STRONG CYP3A4 INHIBITORS/AVANAFIL
  • 3A4INHIB/DAPOXETINE;LEVOMILNACIPRAN(>80MG);VILAZODONE(>20MG)
  • STRONG OR MODERATE CYP3A4 INHIBITORS/FLIBANSERIN
  • PROTEASE INHIBITORS & NNRTIS/COBICISTAT-ELVITEGRAVIR
  • STRONG CYP3A4 INHIBITORS/SLT HIGH STRENGTH ANTIMUSCARINICS
  • SELECTED STRONG CYP3A4 INHIBITORS/DOMPERIDONE; CISAPRIDE
  • STRONG CYP3A4 INHIBITORS; PROTEASE INHIBITORS/TICAGRELOR
  • SELECTED PROTEASE INHIBITORS; COBICISTAT/LURASIDONE
  • HIV PROTEASE INHIBITORS; COBICISTAT/SILDENAFIL (FOR PAH)
  • STRONG CYP3A4 INHIB;ATAZANAV;DARUNAVIR/SAXAGLIPTIN (>2.5 MG)
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR; DARUNAVIR/DRONEDARONE
  • ATAZANAVIR; LOPINAVIR; SIMEPREVIR/ROSUVASTATIN (> 10 MG)
  • P-GP AND STRONG CYP3A4 INHIBITORS/RIVAROXABAN
  • STRONG CYP3A4 INHIBITORS/TOLVAPTAN
  • PROTEASE INHIBITORS/ALFUZOSIN;SILODOSIN;TAMSULOSIN
  • SELECTED PROTEASE INHIBITORS/VARDENAFIL
  • STRONG CYP3A4 INHIBITORS/EPLERENONE
  • STRONG CYP3A4 INHIBITORS/IRINOTECAN
  • SELECTED PROTEASE INHIBITORS; COBICISTAT/ELETRIPTAN
  • SELECTED CYP3A4 INHIBITORS/LOVASTATIN; SIMVASTATIN
  • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SELECTED PROTEASE INHIBITORS/ALPRAZOLAM
  • SELECTED PROTEASE INHIBITORS/CONTRACEPTIVES
  • SELECTED PROTEASE INHIBITORS/RIFABUTIN; RIFAPENTINE
  • PROTEASE INHIBITORS/CARBAMAZEPINE
  • SELECTED PROTEASE INHIBITORS/GARLIC
  • LOPINAVIR/TIPRANAVIR
  • LOPINAVIR/QT PROLONGING AGENTS
  • RITONAVIR & RITONAVIR-BOOSTED PROTEASE INHIBITORS/BOCEPREVIR
  • PROTEASE INHIBITORS/ENZALUTAMIDE
  • STRONG CYP3A4 INHIBITORS/MITAPIVAT
  • STR 3A4 INHIB PROL QT/TOLTERODINE (>1 MG IR OR >2 MG ER)
  • STRONG CYP3A4 INHIBITORS/RIVOCERANIB
  • STRONG CYP3A4 INHIBITORS/DARIDOREXANT
  • STRONG CYP3A4 INHIBITORS/UPADACITINIB (>=30 MG)
  • STRONG CYP3A4 INHIBITORS/RUPATADINE
  • SELECT CYP3A4 INHIBITORS THAT PROLONG QT/TRAZODONE
  • STRONG & MODERATE 3A4 INHIB THAT PROLONG QT/ENCORAFENIB
  • STRONG CYP3A4 INHIBITORS/AVACOPAN
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/RIBOCICLIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/MOBOCERTINIB
  • STRONG 3A4 INHIBITORS THAT PROLONG QT/BEDAQUILINE;DELAMANID
  • STRONG & MODERATE 3A4 INHIBITOR THAT PROLONG QT/FEXINIDAZOLE
  • STRONG CYP3A4 INHIB THAT PROLONG QT/ARTEMETHER;LUMEFANTRINE
  • OATP1B1-3 INHIBITORS/BRINCIDOFOVIR
  • STRONG AND MODERATE CYP3A4 INHIBITORS/INFIGRATINIB
  • SELECTED PROTEASE INHIBITORS/FLECAINIDE; PROPAFENONE
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/PIMAVANSERIN
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/GLASDEGIB
  • DUAL STRONG CYP3A4 INHIBITOR & P-GP INHIBITORS/TEPOTINIB
  • P-GLYCOPROTEIN (P-GP) INHIBITORS/RELUGOLIX
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/TOREMIFENE
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/SUNITINIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/PAZOPANIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/NILOTINIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/LAPATINIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/DASATINIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/CRIZOTINIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/CERITINIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/BOSUTINIB
  • STRONG CYP3A4 INHIBITORS/VINFLUNINE
  • STRONG CYP3A4 INHIBITORS/VINCRISTINE
  • STRONG CYP3A4 INHIBITORS/VINBLASTINE
  • STRONG CYP3A4 INHIBITORS/TOFACITINIB
  • STRONG CYP3A4 INHIBITORS/SONIDEGIB
  • STRONG CYP3A4 INHIBITORS/RUXOLITINIB
  • STRONG CYP3A4 INHIBITORS/PONATINIB
  • STRONG CYP3A4 INHIBITORS/PALBOCICLIB
  • STRONG CYP3A4 INHIBITORS/PACLITAXEL
  • STRONG CYP3A4 INHIBITORS/OLAPARIB
  • STRONG CYP3A4 INHIBITORS/IXABEPILONE
  • STRONG CYP3A4 INHIBITORS/IDELALISIB
  • STRONG CYP3A4 INHIBITORS/ERLOTINIB
  • STRONG CYP3A4 INHIBITORS/DOXORUBICIN
  • STRONG CYP3A4 INHIBITORS/DOCETAXEL
  • STRONG CYP3A4 INHIBITORS/DABRAFENIB
  • STRONG CYP3A4 INHIBITORS/COBIMETINIB
  • STRONG CYP3A4 INHIBITORS/CABOZANTINIB
  • STRONG CYP3A4 INHIBITORS/CABAZITAXEL
  • STRONG CYP3A4 INHIBITORS/AXITINIB
  • STRONG CYP3A4 INHIBITORS/SUVOREXANT
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/IVOSIDENIB
  • STRONG CYP3A4 AND P-GP INHIBITORS/PRALSETINIB
  • STRONG CYP3A4 INHIBITORS/PLITIDEPSIN
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/VEMURAFENIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LURBINECTEDIN
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/QUETIAPINE
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/SELPERCATINIB
  • UGT1A1 INDUCERS/SACITUZUMAB GOVITECAN
  • STRONG AND MODERATE CYP3A4 INHIBITORS/PEMIGATINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/SELUMETINIB
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/OSILODROSTAT
  • STRONG CYP3A4 INHIBITORS/RIMEGEPANT
  • STRONG CYP3A4 INHIBITORS/NIMODIPINE
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/ROMIDEPSIN
  • STRONG CYP3A4 INHIBITORS/TAZEMETOSTAT
  • STRONG CYP3A4 INHIBITORS/AVAPRITINIB
  • SELECTED CYP3A4 INHIBITORS/FLUTICASONE-SALMETEROL
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LUMATEPERONE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LEMBOREXANT
  • P-GLYCOPROTEIN (P-GP) OR UGT INDUCERS/LETERMOVIR
  • POSSIBLE QT PROLONGING AGENTS/HYDROXYCHLOROQUINE
  • STRONG CYP3A4 INHIBITORS/ELEXACAFTOR-TEZACAFTOR-IVACAFTOR
  • STRONG CYP3A4 INHIBITORS/NALDEMEDINE
  • STRONG CYP3A4 INHIBITORS/ISTRADEFYLLINE
  • STRONG CYP3A4 INHIBITORS/FEDRATINIB
  • STRONG CYP3A4 INHIBITORS/ENTRECTINIB
  • STRONG CYP3A4 INHIBITORS/PEXIDARTINIB
  • SELECTED MODERATE CYP2C9 OR CYP3A4 INDUCERS/ERDAFITINIB
  • SELECTED PROTEASE INHIBITORS; COBICISTAT/CLOPIDOGREL
  • SELECTED MODERATE CYP2C9 INDUCERS/SIPONIMOD
  • STRONG CYP3A4 INHIBITORS/LAROTRECTINIB
  • STRONG CYP3A4 INHIBITORS/LORLATINIB
  • WEAK CYP2D6 INHIBITORS/ELIGLUSTAT
  • STRONG CYP3A4 INHIBITORS/DUVELISIB
  • STRONG CYP3A4 INHIBITORS/ELAGOLIX
  • STRONG CYP3A4 INHIBITORS/ARIPIPRAZOLE LAUROXIL SUBMICRONIZED
  • SELECTED PROTEASE INHIBITORS/SODIUM FUSIDATE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/TEZACAFTOR-IVACAFTOR
  • SELECTED INHIBITORS OF BCRP/CLADRIBINE
  • LOPINAVIR-RITONAVIR/OMBITASVIR-PARITAPREVIR
  • SELECTED STRONG CYP3A4 INHIBITOR;PROTEASE INHIB/DISOPYRAMIDE
  • STRONG CYP3A4 INHIBITORS/IBRUTINIB
  • STRONG CYP3A4 INHIBITORS/ACALABRUTINIB
  • STRONG CYP3A4 INHIBITORS/ABEMACICLIB
  • STRONG CYP3A4 INHIBITORS/COPANLISIB
  • DARUNAVIR; LOPINAVIR; RITONAVIR/GLECAPREVIR-PIBRENTASVIR
  • SELECTED OATP INHIBITORS/VOXILAPREVIR
  • STRONG CYP3A4 INHIBITORS/BRIGATINIB
  • STRONG CYP3A4 INHIBITORS/VALBENAZINE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/DEFLAZACORT
  • SELECTED ANTIRETROVIRALS/ORLISTAT
  • STRONG CYP3A4 INHIBITORS/VENETOCLAX
  • STRONG CYP3A4 INHIBITORS/TRABECTEDIN
  • STRONG CYP3A4 INHIBITORS/CARIPRAZINE
  • OATP1B1 INHIBITORS/ELUXADOLINE
  • SLT STRONG CYP3A4 INHIBITOR & SUBSTRATE/LUMACAFTOR-IVACAFTOR
  • RITONAVIR/ISAVUCONAZONIUM
  • STRONG CYP3A4 INHIBITORS/TRASTUZUMAB EMTANSINE
  • STRONG 3A4 INHIBITORS/ESZOPICLONE > 2 MG; ZOPICLONE > 5 MG
  • STRONG & MODERATE CYP3A4 INHIBITORS/ELIGLUSTAT
  • STRONG CYP3A4 INHIBITORS/VORAPAXAR
  • STRONG & MODERATE CYP3A4 INHIBITORS/GUANFACINE
  • STRONG OR MODERATE CYP3A4 INHIBITORS/SIMEPREVIR
  • STRONG CYP3A4 INHIBITORS/MACITENTAN
  • P-GP AND STRONG CYP3A4 INHIBITORS/APIXABAN
  • UGT INDUCERS/CANAGLIFLOZIN
  • STRONG CYP3A4 INHIBITORS; AMPRENAVIR;ATAZANAVIR/MIFEPRISTONE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/IVACAFTOR
  • SELECTED PROTEASE INHIBITORS/TELAPREVIR
  • SELECTED PROTEASE INHIBITORS/QUININE
  • COBICISTAT; HCV OR HIV PROTEASE INHIBITORS/SALMETEROL
  • STRONG UGT INDUCERS/DEFERASIROX
  • RITONAVIR/ULIPRISTAL
  • PROTEASE INHIBITORS/BOSENTAN
  • STRONG CYP3A4 INHIBITORS/EVEROLIMUS
  • SLT PROTEASE INHIBITORS/BARBITURATES;PHENOBARBITAL;PHENYTOIN
  • P-GLYCOPROTEIN (P-GP) INHIBITORS/TOPOTECAN
  • SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/DABIGATRAN
  • SELECTED PROTEASE INHIBITORS/MARAVIROC
  • LOPINAVIR; SAQUINAVIR; OMBITAS-PARITAP-RITONAVIR/DARUNAVIR
  • PROTEASE INH;COBICISTAT/SLT IMMUNOSUPPRESSANTS;TEMSIROLIMUS
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR/COLCHICINE
  • SELECTED CYP3A4 INHIBITORS/SELECTED OPIOIDS
  • SELECTED CYP3A4 INHIBITORS/SELECTED STEROIDS
  • COBICISTAT; RITONAVIR/VORICONAZOLE
  • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • RITONAVIR/BUPROPION
  • RITONAVIR/MEPERIDINE
  • SELECTED PROTEASE INHIBITORS/DIDANOSINE
  • LOPINAVIR/EFAVIRENZ; NEVIRAPINE
  • ATAZANAVIR; RITONAVIR/POSACONAZOLE
  • LOPINAVIR/POSSIBLE QT PROLONGING AGENTS
  • COBICISTAT; RITONAVIR/TENOFOVIR ALAFENAMIDE (> 10 MG)
  • QT PROLONGING AGENTS/TRICLABENDAZOLE
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/GILTERITINIB
  • STR 3A4 INHIBITORS THAT PROLONG QT/PANOBINOSTAT (<= 10 MG)
  • STR 3A4 INHIB THAT PROL QT/TOLTERODINE (<=1 MG OR <=2 MG ER)
  • STRONG CYP3A4 INHIBITORS/UPADACITINIB (<30 MG)
  • STRONG CYP3A4 INHIBITORS/SURUFATINIB
  • OATP1B1-3 INHIBITORS/ATOGEPANT
  • STRONG CYP3A4 INHIBITORS/ATOGEPANT
  • SELECTED POSSIBLE QT PROLONGING AGENTS/INTRAVENOUS LEFAMULIN
  • QT PROLONGING AGENTS/OZANIMOD
  • QT PROLONGING AGENTS/PONESIMOD
  • QT PROLONGING AGENTS/SIPONIMOD
  • STRONG CYP3A4 INHIBITORS THAT PROLONG QT/MIDOSTAURIN
  • STRONG CYP3A4 INHIBITORS/IBREXAFUNGERP
  • SELECTED CYP1A2 INDUCERS/OLANZAPINE-SAMIDORPHAN
  • QT PROLONGING AGENTS/GALANTAMINE
  • STRONG CYP3A4 INHIBITORS/REPAGLINIDE
  • PROTEASE INHIBITORS/SELECTED BENZODIAZEPINES
  • POSSIBLE QT PROLONGING AGENTS/LEVOMEPROMAZINE
  • STRONG CYP2D6 OR CYP3A4 INHIBITORS/OLICERIDINE
  • STRONG CYP3A4 INHIBITORS/FOSTAMATINIB
  • STRONG UGT INDUCERS; NEVIRAPINE/ARTESUNATE
  • POSSIBLE QT PROLONGING AGENTS/OXALIPLATIN
  • QT PROLONGING AGENTS/AMISULPRIDE
  • STRONG CYP3A4 INHIBITORS/CANNABIDIOL-TETRAHYDROCANNABINOL
  • SELECTED STRONG CYP3A4 INHIBITORS/MEFLOQUINE
  • STRONG CYP3A4 INHIBITORS/ZANUBRUTINIB
  • P-GP AND STRONG CYP3A4 INHIBITORS/DAROLUTAMIDE
  • SELECTED STRONG CYP3A4 INHIBITORS/ILOPERIDONE
  • SELECTED PROTEASE INHIBITORS/LIDOCAINE
  • STRONG CYP3A4 INHIBITORS/BREXPIPRAZOLE
  • SELECTED UGT AND STRONG CYP3A4 INDUCERS/OXCARBAZEPINE
  • LAPATINIB; RITONAVIR/EDOXABAN (<= 30 MG)
  • STRONG CYP3A4 INHIBITORS/CLONAZEPAM
  • SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/BETRIXABAN
  • RITONAVIR/THYROID PREPARATIONS
  • SELECTED CYP1A2 INDUCERS/OLANZAPINE
  • SELECTED CYP3A4 INHIBITORS/BROMOCRIPTINE; CABERGOLINE
  • SELECTED CYP3A4 INHIBITORS/FELODIPINE
  • LAPATINIB; RITONAVIR/EDOXABAN (> 30 MG)
  • LOPINAVIR; NELFINAVIR; NEVIRAPINE; RITONAVIR/WARFARIN DERIVS
  • P-GP AND SELECTED CYP3A4 INHIBITORS/NINTEDANIB
  • STRONG 3A4 INHIB/LEVOMILNACIPRAN(<=80MG);VILAZODONE(<=20MG)
  • P-GLYCOPROTEIN (P-GP) INHIBITORS/AFATINIB
  • STRONG CYP3A4 INHIBITORS/REGORAFENIB
  • QT PROLONGING AGENTS/FINGOLIMOD
  • QT PROLONGING AGENTS/VORICONAZOLE
  • BOCEPREVIR; RITONAVIR; TELAPREVIR/DIGOXIN
  • POSSIBLE QT PROLONGING AGENTS/GADOFOSVESET
  • RITONAVIR/LEVOMETHADONE; METHADONE
  • LOPINAVIR; RITONAVIR/LAMOTRIGINE
  • HIV PROTEASE INHIBITORS;COBICISTAT/SILDENAFIL (ED);TADALAFIL
  • STRONG CYP3A4 INHIB;ATAZANAV;DARUNAVIR/SAXAGLIPTIN(<=2.5 MG)
  • ATAZANAVIR; LOPINAVIR; SIMEPREVIR/ROSUVASTATIN (<= 10 MG)
  • SELECTED WEAK CYP2D6 INHIBITORS/TAMOXIFEN
  • CYP3A4; CYP2C8; P-GLYCOPROTEIN (P-GP) INHIBITORS/LOPERAMIDE
  • STRONG CYP3A4 INHIBITORS/BUSPIRONE
  • LOPINAVIR/SELECTED PROTEASE INHIBITORS
  • QT PROLONGING AGENTS/NORFLOXACIN
  • STRONG CYP3A4 INHIBITORS/ESZOPICLONE; ZOPICLONE; ZOLPIDEM
  • SELECTED CYP3A4 INHIBITORS/ITRACONAZOLE; KETOCONAZOLE
  • STRONG CYP3A4 INHIBITORS/CINACALCET
  • SELECTED PROTEASE INHIBITORS/SELECTED ANTIARRHYTHMICS
  • SELECTED PROTEASE INHIBITORS/ATORVASTATIN
  • STRONG CYP3A4 INHIBITORS; ATAZANAVIR; DARUNAVIR/ARIPIPRAZOLE
  • SELECTED PROTEASE INHIBITORS/CLARITHROMYCIN
  • STRONG CYP3A4 INHIBITORS/SLT LOW STRENGTH ANTIMUSCARINICS
  • SLT STRONG & MODERATE CYP3A4 INHIBITORS/CILOSTAZOL (<=50MG)
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    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.