Cyclosporine/Amiodarone Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process cyclosporine properly.

What might happen:

Your blood levels of cyclosporine may increase and cause kidney damage.

What you should do about this interaction:

If your doctor prescribes these medicines together, you may need to have blood levels of cyclosporine and kidney tests more regularly monitored. You may need an adjustment in the dose of your cyclosporine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Nicolau DP, Uber WE, Crumbley AJ 3rd, Strange C. Amiodarone-cyclosporine interaction in a heart transplant patient. J Heart Lung Transplant 1992 May-Jun;11(3 Pt 1):564-8.
  • 2.Chitwood KK, Abdul-Haqq AJ, Heim-Duthoy KL. Cyclosporine-amiodarone interaction. Ann Pharmacother 1993 May;27(5):569-71.
  • 3.Mamprin F, Mullins P, Graham T, Kendall S, Biocine B, Large S, Wallwork J, Schofield P. Amiodarone-cyclosporine interaction in cardiac transplantation. Am Heart J 1992 Jun;123(6):1725-6.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.