Selected Kinase Inhibitors/Proton Pump Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The pH of your GI tract needs to be acidic for your medicine to dissolve and be absorbed. Proton pump inhibitors change the pH (acidity) in your GI tract.

What might happen:

The amount of medicine in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may instruct you to take antacids instead of your proton pump inhibitor.If you need to use an antacid while on dasatinib or nilotinib, take the antacid at least 2 hours before or 2 hours after your dasatinib or nilotinib.If you need to use an antacid while on neratinib, take the antacid at least 3 hours before your neratinib.If you need to use an antacid while on bosutinib, erlotinib, or pazopanib, separate the doses of the antacid and your cancer medicine by several hours.If you have questions about how to schedule your medicines, ask your pharmacist.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Bosulif (bosutinib) US prescribing information. Pfizer Inc. November, 2016.
  • 2.Sprycel (dasatinib) US prescribing information. Bristol-Myers Squibb Company August, 2015.
  • 3.Tarceva (erlotinib) US prescribing information. Genentech, Inc. October, 2016.
  • 4.Nerlynx (neratinib) US prescribing information. Puma Biotechnology, Inc. July, 2017.
  • 5.Tasigna (nilotinib) US prescribing information. Novartis Pharmaceuticals Corporation February 21, 2017.
  • 6.Votrient (pazopanib) US prescribing information. GlaxoSmithKline May, 2017.
  • 7.Ter Heine R, Fanggiday JC, Lankheet NA, Beijnen JH, Van Der Westerlaken MM, Staaks GH, Malingre MM. Erlotinib and pantoprazole: a relevant interaction or not?. Br J Clin Pharmacol 2010 Dec;70(6):908-11.
  • 8.Yin OQ, Gallagher N, Fischer D, Demirhan E, Zhou W, Golor G, Schran H. Effect of the Proton Pump Inhibitor Esomeprazole on the Oral Absorption and Pharmacokinetics of Nilotinib. J Clin Pharmacol 2010 May 24.
  • 9.Tan AR, Gibbon DG, Stein MN, Lindquist D, Edenfield JW, Martin JC, Gregory C, Suttle AB, Tada H, Botbyl J, Stephenson JJ. Effects of ketoconazole and esomeprazole on the pharmacokinetics of pazopanib in patients with solid tumors. Cancer Chemother Pharmacol 2013 Jun;71(6):1635-43.
  • 10.Quinn DI, Nemunaitis J, Fuloria J, Britten CD, Gabrail N, Yee L, Acharya M, Chan K, Cohen N, Dudov A. Effect of the cytochrome P450 2C19 inhibitor omeprazole on the pharmacokinetics and safety profile of bortezomib in patients with advanced solid tumours, non-Hodgkin's lymphoma or multiple myeloma. Clin Pharmacokinet 2009;48(3):199-209.