If you are:
Not Recommended: BASED ON DRUG PHARMACOLOGY DEVELOPMENTAL TOXICITY IS POSSIBLE
Absolute Contraindication: CAUTION ADVISED; POTENTIAL SERIOUS EFFECTS ON INFANT
An adult over 60:
management or monitoring precaution: Cardiovascular-Greater risk of edema. Monitor patients with underlying CHF, establish baseline left ventricular function. Renal-Adjust dose for mild to moderate renal impairment. Increased risk of renal toxicity with prolonged therapy.
Giving Gleevec to a child under 12:
Severe Precaution: Reports of slowed growth rate. No safety and efficacy data age < 1 year.
management or monitoring precaution: Monitor closely for slowed growth rate.