NSAIDs/Corticosteroids Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, they may increase chances for stomach problems.

What might happen:

Your risk of developing a bleeding stomach ulcer.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and if you have a history of stomach ulcers or bleeding, smoke, use alcohol regularly, and/or are taking a blood thinner. If you experience stomach pain, stomach upset, or notice black, tarry stools, contact your doctor as soon as possible. It may be necessary to adjust the dose of your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Emmanuel JH, Montgomery RD. Gastric ulcer and the anti-arthritic drugs. Postgrad Med J 1971 Apr;47(546):227-32.
  • 2.Indocin (indomethacin) US prescribing information. Merck & Co., Inc. May, 2016.
  • 3.Celebrex (celecoxib) US prescribing information. Pfizer Inc. May, 2016. 4.Feldene (piroxicam) US prescribing information. Pfizer Inc. May, 2016.