IFOSFAMIDE-MESNA Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • an infection
  • anemia
  • decreased blood platelets
  • low levels of white blood cells
  • low levels of a type of white blood cell called neutrophils
  • damage to the liver and inflammation
  • inflammation of the bladder with hemorrhage
  • difficult or painful urination
  • an increased need to urinate often
  • low levels of granulocytes, a type of white blood cell

If experienced, these tend to have a Less Severe expression i

  • hair loss
  • drowsiness
  • nausea
  • vomiting
  • anemia
  • constipation
  • fever
  • low energy
  • decreased appetite
  • headache
  • diarrhea
  • generalized weakness
  • intense abdominal pain

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • confusion
  • damage to the kidneys

If experienced, these tend to have a Less Severe expression i

  • fever
  • inflammation of the vein, or phlebitis after infusion
  • visual sensitivity to light
  • pink eye
  • high blood pressure
  • low blood pressure
  • stuffy nose
  • dry mouth
  • joint pain
  • backache
  • dizziness
  • flu-like symptoms
  • excessive sweating
  • chills
  • taste impairment
  • numbness
  • swollen lymph nodes
  • cough
  • difficult or painful urination
  • reactions at the site of the injection
  • a feeling of pins and needles on skin

RARE side effects

If experienced, these tend to have a Severe expression i

  • a systemic inflammatory response called sepsis due to an infection with bacteria
  • shingles
  • opportunistic fungal infection
  • pneumonia with a fungus called Pneumocystis jirovecii
  • renal cell carcinoma
  • acute leukemia
  • thyroid cancer
  • a disorder with excess antidiuretic hormone called syndrome of inappropriate antidiuretic hormone
  • excess body acid
  • a reduction in the body's resistance to infection
  • hemolytic uremic syndrome, a condition that affects the kidney and the blood
  • significantly decreased activity of the bone marrow
  • a type of blood clotting disorder called disseminated intravascular coagulation
  • very low levels of granulocytes, a type of white blood cell
  • methemoglobinemia, a type of blood disorder
  • mental problems from taking the drug
  • extrapyramidal disease, a type of movement disorder
  • a type of brain function problem called encephalopathy
  • a toxic effect on the central nervous system, which consists of the brain and spinal cord
  • generalized disorder of peripheral nerves
  • toxicity to the nerve that controls hearing
  • high blood pressure
  • a heart attack
  • a clot in the lung
  • fluid in the covering of the heart or pericardium
  • cardiomyopathy, a disease of the heart muscle
  • bundle branch block
  • abnormal heart electrical signals
  • supraventricular tachycardia
  • rapid ventricular heartbeat
  • atrial fibrillation
  • premature atrial heartbeats
  • ventricular premature beats
  • ventricular arrhythmias, a type of abnormal heart rhythm
  • supraventricular arrhythmias, a type of abnormal heart rhythm
  • chronic heart failure
  • toxicity to the heart
  • inflammation of the blood vessels
  • capillary leak syndrome, a condition where fluid leaks out of small blood vessels
  • hepatic veno-occlusive disease, a type of liver disease
  • blood clot in a deep vein of the extremities
  • low blood pressure
  • a type of inflammation of the lung called interstitial pneumonitis
  • a condition where there is formation of fibrous tissue in the lung called pulmonary fibrosis
  • stomatitis, a condition with painful swelling and sores inside the mouth
  • myelodysplastic syndrome, a bone marrow disorder
  • coma
  • hallucinations
  • seizures
  • a significant drop in blood pressure due to bacterial infection
  • trouble breathing
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • malignant lymphoma
  • diabetes insipidus with kidney complications
  • progressive multifocal leukoencephalopathy, a type of brain infection
  • multiple organ failure
  • therapy-related acute myeloid leukemia
  • excess fibrous tissue around covering of heart
  • an increased risk of developing an uncommon viral infection called an opportunistic infection
  • radiation recall syndrome
  • tumor lysis syndrome
  • increased eosinophils in the blood
  • ST segment changes on an EKG
  • inflammation of the liver called hepatitis
  • inflammation of the skin due to an allergy
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • coughing up of blood
  • abnormal liver function tests

If experienced, these tend to have a Less Severe expression i

  • panic disorder
  • a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
  • blurred vision
  • pink eye
  • ringing in the ears
  • hearing loss
  • excessive saliva production
  • constipation
  • low sperm count
  • absence of menstrual periods
  • skin inflammation
  • itching
  • darkening of the skin
  • delirium
  • memory loss
  • sensation of spinning or whirling
  • low energy
  • chills
  • temporary redness of face and neck
  • decreased appetite
  • excessive thirst
  • involuntary leakage of urine
  • excess urination
  • impaired wound healing
  • a feeling of general discomfort called malaise
  • intense abdominal pain
  • throat irritation
  • muscle pain
  • a skin rash
  • rapid breathing
  • fast heartbeat
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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.