Does METHADONE HCL Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • LEVOMETHADONE;LEVOMETHADYL;METHADONE/ITRACONAZOLE;KETOCONAZO
  • METHADONE/SELECTED MAOIS
  • LEVOMETHADONE; METHADONE/SAFINAMIDE
  • METHADONE FOR MAT/SELECTED ANTIPSYCHOTICS THAT PROLONG QT
  • METHADONE (NON MAT)/SELECTED ANTIPSYCHOTICS THAT PROLONG QT
  • LEVOMETHADONE; METHADONE/POSACONAZOLE
  • METHADONE (IMMEDIATE RELEASE)/METAXALONE
  • SELECTED OPIOIDS FOR MAT/METAXALONE
  • QT PROLONGING AGENTS/LEVOKETOCONAZOLE
  • QT PROLONGING AGENTS/HYDROXYCHLOROQUINE
  • QT PROLONGING AGENTS/ANAGRELIDE
  • QT PROLONGING AGENTS/DOMPERIDONE
  • LEVOMETHADONE;METHADONE/DIDANOSINE PEDIATRIC POWDER FOR SUSP
  • QT PROLONGING AGENTS/DRONEDARONE
  • QT PROLONGING AGENTS/ARTEMETHER-LUMEFANTRINE
  • QT PROLONGING AGENTS/DISOPYRAMIDE
  • QT PROLONGING AGENTS/CISAPRIDE
  • QT PROLONGING AGENTS/LEVOMETHADYL
  • QT PROLONGING AGENTS/SPARFLOXACIN
  • QT PROLONGING AGENTS/HALOFANTRINE
  • QT PROLONGING AGENTS/BEPRIDIL
  • OPIOID ANALGESICS/OPIOID ANTAGONISTS
  • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • CHRONIC OPIOIDS/NALBUPHINE
  • LEVOMETHADONE; METHADONE/FLUCONAZOLE; VORICONAZOLE
  • LEVOMETHADONE; METHADONE/SELECTED ANTIARRHYTHMICS
  • LEVOMETHADONE; METHADONE/QT PROLONGING AGENTS
  • CHRONIC OPIOIDS/BUTORPHANOL
  • CHRONIC OPIOIDS/BUPRENORPHINE
  • METHADONE FOR MAT/SELECTED ANTIPSYCHOTICS THAT PROLONG QT
  • METHADONE (NON MAT)/SELECTED ANTIPSYCHOTICS THAT PROLONG QT
  • FENTANYL; LEVOMETHADONE; METHADONE/LINEZOLID
  • QT PROLONGING AGENTS/PACRITINIB
  • QT PROLONGING AGENTS/PANOBINOSTAT
  • QT PROLONGING AGENTS/MOBOCERTINIB
  • QT PROLONGING AGENTS/FEXINIDAZOLE
  • ANTICHOLINERGICS; OPIOIDS/ELUXADOLINE
  • QT PROLONGING AGENTS/PAZOPANIB
  • QT PROLONGING AGENTS/SELPERCATINIB
  • QT PROLONGING AGENTS/OXALIPLATIN
  • QT PROLONGING AGENTS/LEFAMULIN
  • QT PROLONGING AGENTS/ENTRECTINIB
  • QT PROLONGING AGENTS/GLASDEGIB
  • WEAK CYP2D6 INHIBITORS/ELIGLUSTAT
  • QT PROLONGING AGENTS/IVOSIDENIB
  • QT PROLONGING AGENTS/ENCORAFENIB
  • QT PROLONGING AGENTS/LOFEXIDINE
  • QT PROLONGING AGENTS/MACIMORELIN
  • QT PROLONGING AGENTS/INOTUZUMAB OZOGAMICIN
  • QT PROLONGING AGENTS/RIBOCICLIB
  • QT PROLONGING AGENTS/HYDROXYZINE
  • QT PROLONGING AGENTS/VEMURAFENIB
  • QT PROLONGING AGENTS/TELAVANCIN
  • QT PROLONGING AGENTS/SORAFENIB
  • QT PROLONGING AGENTS/ROMIDEPSIN
  • QT PROLONGING AGENTS/ONDANSETRON
  • QT PROLONGING AGENTS/LENVATINIB
  • QT PROLONGING AGENTS/GADOFOSVESET
  • QT PROLONGING AGENTS/EZOGABINE
  • QT PROLONGING AGENTS/CRIZOTINIB
  • QT PROLONGING AGENTS/CERITINIB
  • QT PROLONGING AGENTS/BEDAQUILINE
  • QT PROLONGING AGENTS/ARSENIC
  • QT PROLONGING AGENTS/OSIMERTINIB
  • QT PROLONGING AGENTS/PROPOFOL
  • QT PROLONGING AGENTS/PENTAMIDINE
  • QT PROLONGING AGENTS/ERYTHROMYCIN
  • QT PROLONGING AGENTS/DONEPEZIL
  • QT PROLONGING AGENTS/CILOSTAZOL
  • QT PROLONGING AGENTS/CHLOROQUINE
  • QT PROLONGING AGENTS/AZITHROMYCIN
  • QT PROLONGING AGENTS/HYDROQUINIDINE; QUINIDINE
  • QT PROLONGING AGENTS/DELAMANID
  • QT PROLONGING AGENTS/CITALOPRAM
  • QT PROLONGING AGENTS/TRAZODONE (>= 100 MG)
  • AGENTS THAT MAY CAUSE RESPIRATORY DEPRESSION/SODIUM OXYBATE
  • QT PROLONGING AGENTS/VANDETANIB
  • QT PROLONGING AGENTS/PROPAFENONE
  • QT PROLONGING AGENTS/SAQUINAVIR
  • QT PROLONGING AGENTS/QUININE
  • QT PROLONGING AGENTS/LOPINAVIR
  • QT PROLONGING AGENTS/TOREMIFENE
  • QT PROLONGING AGENTS/NILOTINIB
  • QT PROLONGING AGENTS/IVABRADINE
  • QT PROLONGING AGENTS/AMIODARONE
  • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • LEVOMETHADONE; METHADONE/FLUVOXAMINE
  • LEVOMETHADONE; METHADONE/POSSIBLE QT PROLONGING AGENTS
  • LEVOMETHADONE; METHADONE/EFAVIRENZ; NEVIRAPINE
  • LEVOMETHADONE; METHADONE/RITONAVIR
  • OPIOIDS (IMMEDIATE RELEASE)/BENZODIAZEPINES
  • OPIOIDS (IMMEDIATE RELEASE)/SLEEP DRUGS; TRANQUILIZERS
  • SELECTED OPIOIDS FOR MAT/BENZODIAZEPINES
  • SELECTED OPIOIDS FOR MAT/SLEEP DRUGS; TRANQUILIZERS
  • SELECTED OPIOIDS FOR MAT/ANTIPSYCHOTICS
  • METHADONE (NON MAT)/SELECTED ANTIPSYCHOTICS; PHENOTHIAZINES
  • OPIOIDS (IMMEDIATE RELEASE)/SELECTED STIMULANTS
  • LEVOMETHADONE; METHADONE/CYP2B6 AND SELECTED CYP3A4 INDUCERS
  • METHADONE (IMMEDIATE RELEASE)/SELECTED MUSCLE RELAXANTS
  • METHADONE (IMMEDIATE RELEASE)/TIZANIDINE
  • SELECTED OPIOIDS FOR MAT/SELECTED MUSCLE RELAXANTS
  • METHADONE FOR MAT/TIZANIDINE
  • SELECTED OPIOIDS FOR MAT/BREXPIPRAZOLE
  • METHADONE (NON MAT)/BREXPIPRAZOLE
  • LEVOMETHADONE; METHADONE/CYP2B6 INHIBITORS
  • LEVOMETHADONE; METHADONE/PAROXETINE
  • SENSITIVE CYP2B6 SUBSTRATES THAT PROLONG QT/MIDOSTAURIN
  • SELECTED SENSITIVE CYP2B6 SUBSTRATES/LEMBOREXANT
  • QT PROLONGING AGENTS/TRICLABENDAZOLE
  • QT PROLONGING AGENTS/TOLTERODINE
  • QT PROLONGING AGENTS/OZANIMOD
  • QT PROLONGING AGENTS/PONESIMOD
  • QT PROLONGING AGENTS/SIPONIMOD
  • QT PROLONGING AGENTS/GALANTAMINE
  • SELECTED WEAK CYP2D6 INHIBITORS/TAMOXIFEN
  • QT PROLONGING AGENTS/OSILODROSTAT
  • QT PROLONGING AGENTS/PITOLISANT
  • QT PROLONGING AGENTS/GILTERITINIB
  • AGENTS WITH HYPONATREMIA RISK/DESMOPRESSIN
  • QT PROLONGING AGENTS/TRAZODONE (< 100 MG)
  • AGENTS WITH HYPONATREMIA RISK/DESMOPRESSIN (NOCTURIA)
  • QT PROLONGING AGENTS/ERIBULIN
  • QT PROLONGING AGENTS/PASIREOTIDE
  • QT PROLONGING AGENTS/FINGOLIMOD
  • OPIOIDS (IR & ER)/GABAPENTINOIDS
  • QT PROLONGING AGENTS/RANOLAZINE
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    Drug Survey

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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.