Troglitazone/Contraceptives Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may process the medicine in birth control pills more quickly.

What might happen:

The effects of your birth control pills may decrease and cause breakthrough bleeding, spotting, or pregnancy.

What you should do about this interaction:

Talk to your healthcare professional (e.g. doctor or pharmacist) as soon as possible about using a different form of birth control. Contact your doctor if you experience breakthrough bleeding, spotting, or pregnancy.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Rezulin (troglitazone) US prescribing information. Parke-Davis August, 1997.
  • 2.Loi CM, Stern R, Koup JR, Vassos AB, Knowlton P, Sedman AJ. Effect of troglitazone on the pharmacokinetics of an oral contraceptive agent. J Clin Pharmacol 1999 Apr;39(4):410-7.