Progestin-Containing Contraceptives/Ulipristal Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Ulipristal may decrease the effectiveness of other hormonal contraceptive products.

What might happen:

Your hormonal contraceptive (including combination products, progestin-only products, and levonorgestrel emergency contraception) may not be as effective.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. If you are taking a combination contraceptive or a progestin-only product, you should use a reliable barrier method of contraception during intercourse until your next menstrual cycle begins. Discuss alternatives to levonorgestrel emergency contraception with your healthcare provider.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Ellaone (ulipristal acetate) UK summary of product characteristics. HRA Pharma UK Ltd May 15, 2009.
  • 2.Ella (ulipristal acetate) US prescribing information. Afaxys Inc May, 2018.
  • 3.Fibristal (ulipristal acetate) Canadian prescribing information. Actavis Specialty Pharmaceuticals Co. January 28, 2015.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.