What should I Know Regarding Pregnancy, Nursing and Administering PE-PPA-Phenir-Pyril-Hydrocod Solution to Children or the Elderly?

If you are PREGNANT

  • FDB Only When Necessary: NO FDA CATEGORY; INCR RISK OF RETROLENTAL FIBROPLASIA SEEN IN PREMATURE INFANTS
  • Only When Necessary: NEONATAL WITHDRAWAL/RESP.DEPRESS. W/CHRONIC OR HIGH DOSE; SMALL TERATOGENIC RISK
  • Only When Necessary: EVIDENCE FOR MALFORMATIONS; CAN REDUCE UTERINE BLOOD FLOW CAUSING FETAL HYPOXIA
  • FDB Only When Necessary: ANTIHIST USE LAST 2 WKS OF PREG ASSOC W/RETROLENTAL FIBROPLASIA IN PREMATURE INF

If you are NURSING

  • Precaution: INSUFFICIENT DATA AVAILABLE.
  • Precaution: MONITOR FOR CHANGES IN RESPIRATION, GI EFFECTS, SEDATION, FEEDING PATTERNS
  • Precaution: ORAL BIOAVAILABILITY LOW; INFANT EXPOSURE MAY BE MINIMAL
  • Precaution: INSUFF DATA AVAIL; MOLECULAR WT LOW ENOUGH FOR POSSIBLE BREASTMILK EXCRETION
  • Precaution: USE IS NOT RECOMMENDED; MAY CAUSE UNUSUAL EXCITEMENT OR IRRITABILITY

If you are an adult over 60

  • management or monitoring precaution: Pulmonary-Respiratory depression is more likely to occur in elderly, as they may have altered pharmacokinetics due to poor fat stores, muscle wasting, or altered clearance. Neuro/Psych-Risk for confusion, delirium and falls. Avoid treatment with 3 or more CNS active agents. Gastrointestinal-Constipation risk. Renal-Impaired function may lead to increased toxicity due to accumulation of parent compound and metabolites. Cardiovascular-Monitor for hypotension with high doses.
  • management or monitoring precaution: Cardiovascular-Elderly are more sensitive to tachycardia and hypertensive effects. May exacerbate symptomatic coronary insufficiency. Genitourinary-May cause urinary retention. Neuro/Psych-May worsen cognitive impairment in some elderly with dementia. Insomnia risk.
  • management or monitoring precaution: Neuro/Psych-Anticholinergic effects may cause sedation, worsen cognitive impairment and increase fall risk. Non-sedating antihistamine preferred. Gastrointestinal-May cause or worsen pre-existing constipation. Genitourinary-Best avoided in patients with urinary retention from any cause.
  • management or monitoring precaution: Increased risk of hypotension, hyperexcitability, and anticholinergic side effects.

Giving PE-PPA-Phenir-Pyril-Hydrocod Solution to a child under 12

  • Contraindication: Do not use in pediatrics <6 years of age unless clinician consultation.
  • Contraindication: Risk of respiratory depression, breathing problems. Contraindicated age< 6 years.
  • Contraindication: Possible CNS excitation and seizure risk in newborns.
  • Contraindication: Risk of CNS excitation. Do not use age <6 years without clinician consult.
  • Contraindication: Possible CNS excitation and seizure risk in newborns.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.