Amphetamines/Antacids;H2 Antagonists;Proton Pump Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Antacids and proton pump inhibitors may increase the amount of amphetamine that gets into your body.

What might happen:

Taking these together may increase the effect of amphetamines.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you medicine is not working or you have more side effects than expected. Your doctor may tell you not to take your amphetamine at the same time as your antacid.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Adderall XR (amphetamine) US prescribing information. Shire US Inc. April, 2015.
  • 2.Adderall (amphetmine) US prescribing information. Barr Laboratories, Inc. January, 2017.
  • 3.Adderall XR (amphetamine) Canadian prescribing information. Shire Canada Inc. September 30, 2009.
  • 4.Haffey MB, Buckwalter M, Zhang P, Homolka R, Martin P, Lasseter KC, Ermer JC. Effects of omeprazole on the pharmacokinetic profiles of lisdexamfetamine dimesylate and extended-release mixed amphetamine salts in adults. Postgrad Med 2009 Sep;121(5):11-9.