Selected HMG-CoA Reductase Inhibitors/Fusidic Acid Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Fusidic acid may slow down how quickly your liver processes your cholesterol medicine.

What might happen:

The amount of your cholesterol medicine in your blood may increase and damage your muscles.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want to change your cholesterol medicine or have you stop taking your cholesterol medicine while you are taking your antibiotic. Let your doctor know if you experience any unexplained muscle pain, tenderness, weakness, and/or discoloration of the urine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Fucidin (fusidic acid) UK summary of product characteristics. Leo Laboratories Lmited October 24, 2012.
  • 2.Ede M. Dear Canadian Healthcare Professional: Subject: ZOCOR (simvastatin) - New Safety Recommendations on Dosage Associated with the Increased Risk of Myopathy/Rhabdomyolysis. Merck Canada Inc. November 7, 2012.
  • 3.Burtenshaw AJ, Sellors G, Downing R. Presumed interaction of fusidic acid with simvastatin. Anaesthesia 2008 Jun;63(6):656-8.
  • 4.Yuen SL, McGarity B. Rhabdomyolysis secondary to interaction of fusidic acid and simvastatin. Med J Aust 2003 Aug 4;179(3):172.
  • 5.Kotanko P, Kirisits W, Skrabal F. Rhabdomyolysis and acute renal graft impairment in a patient treated with simvastatin, tacrolimus, and fusidic acid. Nephron 2002 Feb;90(2):234-5.
  • 6.Dromer C, Vedrenne C, Billey T, Pages M, Fournie B, Fournie A. Rhabdomyolysis due to simvastin. Apropos of a case with review of the literature. Rev Rhum Mal Osteoartic 1992 Apr;59(4):281-3.
  • 7.Wenisch C, Krause R, Fladerer P, El Menjawi I, Pohanka E. Acute rhabdomyolysis after atorvastatin and fusidic acid therapy. Am J Med 2000 Jul;109(1):78.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.