Leflunomide; Teriflunomide/Methotrexate Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, harmful effects on your liver, blood, and/or lungs may result.

What might happen:

You may experience an increased chance for toxic effects to your liver. Nausea, stomach pain, yellowing of the skin or eyes, dark urine, fever, or fatigue may be signs of liver problems. The number of cells in your blood may decrease. You may become tired easily, may bleed or bruise more easily, and may be more likely to get an infection. There is a small risk that you could develop an inflammation in your lungs.

What you should do about this interaction:

Be sure to get all of the blood tests that your doctor orders. If you have any symptoms of liver or blood problems, contact your doctor. Contact your doctor right away if you have any new or worsening of shortness of breath and/or cough, with or without a fever. It may be necessary to change one or both of your medicines.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Arava (leflunomide) US prescribing information. Aventis Pharmaceuticals, Inc. November, 2012.
  • 2.Dear Healthcare Professional: Arava (leflunomide) and interstitial lung disease. Aventis Pharma, Inc. June 21, 2004.
  • 3.Aubagio (teriflunomide) US prescribing information. Genzyme Corporation June, 2016.