Methotrexate (Anti-Rheumatic) Oral Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • a systemic inflammatory response called sepsis due to an infection with bacteria
  • a bacterial infection
  • decreased blood platelets
  • low levels of white blood cells
  • canker sores
  • stomach or intestinal ulcer
  • bleeding of the stomach or intestines
  • abnormally high levels of nitrogen-containing compounds in your blood
  • abnormal liver function tests
  • If experienced, these tend to have a Less Severe expression i

  • inflammation of the gums and mouth
  • hair loss
  • dizziness
  • low energy
  • decreased appetite
  • headache
  • nausea
  • a feeling of general discomfort called malaise
  • intense abdominal pain
  • a stinging sensation on the skin
  • INFREQUENT side effects

    If experienced, these tend to have a Severe expression i

  • anemia
  • leukoencephalopathy, a disease of the white matter of the brain
  • a condition where there is formation of fibrous tissue in the lung called pulmonary fibrosis
  • liver tissue death
  • hardening of the liver
  • damage to the liver and inflammation
  • If experienced, these tend to have a Less Severe expression i

  • throat irritation
  • furunculosis or boils on the skin
  • itching
  • fever
  • chills
  • a skin rash
  • vomiting
  • RARE side effects

    If experienced, these tend to have a Severe expression i

  • an unusual viral infection called cytomegalovirus infection
  • opportunistic fungal infection
  • pneumonia with a fungus called Pneumocystis jirovecii
  • diabetes
  • a type of blood disorder with a decrease in all types of blood cells called pancytopenia
  • low blood counts due to bone marrow failure
  • very low levels of granulocytes, a type of white blood cell
  • low levels of a type of white blood cell called neutrophils
  • increased eosinophils in the blood
  • inflammation of the arachnoid, one of the membranes covering the brain and spinal column
  • subacute necrotizing encephalomyelopathy, a type of brain dysfunction
  • hemiplegia
  • a type of brain function problem called encephalopathy
  • increased spinal fluid pressure
  • temporary blindness
  • optic neuropathy, a disease of the optic nerve
  • a clot in the lung
  • inflammation of the covering of the heart or pericardium
  • fluid in the covering of the heart or pericardium
  • a blood clot in the brain
  • obstruction of a blood vessel by a blood clot
  • a blood clot in an artery
  • inflammation of blood vessels in the skin
  • thrombophlebitis, an inflamed vein due to a blood clot
  • blood clot in a deep vein of the extremities
  • low blood pressure
  • a type of inflammation of the lung called interstitial pneumonitis
  • inflammation of the alveoli of the lungs
  • lung failure causing loss of breath
  • a hole in the intestine
  • acute liver failure
  • excess liver fibrous tissue
  • kidney failure
  • decreased kidney function
  • increased sensitivity of the skin to the sun
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • skin rash with sloughing
  • seizures
  • dead skin
  • elevation of proteins in the urine
  • a broken bone
  • a significant type of allergic reaction called anaphylaxis
  • a rupture in the wall of the stomach or intestine
  • bleeding from the lungs
  • a type of immune system problem called hypogammaglobulinemia
  • pancreatitis
  • progressive multifocal leukoencephalopathy, a type of brain infection
  • osteonecrosis, the death of bone tissue due to a lack of blood supply
  • a blood clot in a retinal vein
  • tumor lysis syndrome
  • bleeding and inflammation of the small intestine
  • If experienced, these tend to have a Less Severe expression i

  • an infection
  • confusion
  • altered interest in having sexual intercourse
  • blurred vision
  • pink eye
  • dry eye
  • ringing in the ears
  • small red skin lesions due to dilated blood vessels
  • stomatitis, a condition with painful swelling and sores inside the mouth
  • inflammation of the bladder
  • bloody urine
  • low sperm count
  • the inability to have an erection
  • enlarged breasts
  • a problem with menstrual periods
  • acne
  • joint pain
  • muscle pain
  • drowsiness
  • aphasia, a loss of the ability to speak and understand language
  • a type of speech disorder called dysarthria
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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.