Methotrexate (Anti-Rheumatic) Tablet Side Effects by Likelihood and Severity

COMMON side effects


If experienced, these tend to have a Severe expression

  • Azotemia
  • Bleeding Of The Stomach Or Intestines
  • Canker Sore
  • Decreased Blood Platelets
  • Hole In The Intestine
  • Infection Caused By Bacteria
  • Inflammation Of The Lining Of The Stomach And Intestines
  • Sepsis Caused By Bacteria
  • Stomach Or Intestinal Ulcer
  • Sun-Sensitive Skin

If experienced, these tend to have a Less Severe expression

  • Dizzy
  • Feel Like Throwing Up
  • Inflammation Of The Gums And Mouth
  • Loss Of Appetite
  • Low Energy
  • Not Feeling Well
  • Throwing Up

INFREQUENT side effects


If experienced, these tend to have a Severe expression

  • Anemia
  • Arachnoid Membrane Inflammation Caused By Chemicals
  • Decreased White Blood Cells
  • Disease In The White Matter Area Of The Brain
  • Hardening Of The Liver
  • Hepatitis Caused By Drugs
  • Interstitial Pneumonitis
  • Liver Tissue Death
  • Lung Fibrosis

If experienced, these tend to have a Less Severe expression

  • Abnormal Liver Function Tests
  • Acne
  • Chills
  • Diarrhea
  • Fever
  • Hair Loss
  • Itching
  • Presence Of Boils On The Skin
  • Rash
  • Throat Irritation

RARE side effects


If experienced, these tend to have a Severe expression

  • A Disease Causing Brain Dysfunction - Leigh's Disease
  • Acquired Decrease Of All Cells In The Blood
  • Acute Liver Failure
  • Avascular Necrosis Of Bone
  • Blood Clot In A Deep Vein Of The Extremities
  • Blood Clot In An Artery
  • Blood Clot In The Brain
  • Blood Clot In Vein
  • Blood Clot Of A Vein Of The Retina
  • Broken Bone
  • Decreased Neutrophils A Type Of White Blood Cell
  • Deficiency Of Granulocytes A Type Of White Blood Cell
  • Diabetes
  • Disorder Of The Brain
  • Elevation Of Proteins In The Urine
  • Erythema Multiforme
  • Excess Liver Fibrous Tissue
  • Fluid In The Covering Of The Heart Or Pericardium
  • Hemiplegia
  • Increased Eosinophils In The Blood
  • Increased Spinal Fluid Pressure
  • Increased Uric Acid Due To Cancer Chemotherapy
  • Inflammation Of Blood Vessels In The Skin
  • Inflammation Of The Alveoli Of The Lungs
  • Inflammation Of The Covering Of The Heart Or Pericardium
  • Kidney Disease With Reduction In Kidney Function
  • Kidney Failure
  • Life Threatening Allergic Reaction
  • Low Blood Counts Due To Bone Marrow Failure
  • Lung Embolism
  • Lung Failure Causing Loss Of Breath
  • Pneumonia Caused By Pneumocystis Jirovecii Organism
  • Seizures
  • Skin Rash With Sloughing
  • Stevens-Johnson Syndrome
  • Temporary Blindness
  • Toxic Epidermal Necrolysis

If experienced, these tend to have a Less Severe expression

  • Altered Interest In Having Sexual Intercourse
  • Bloody Urine
  • Blurred Vision
  • Brain Disease Or Injury Causing Inability To Communicate
  • Confused
  • Drowsiness
  • Dysarthria
  • Head Pain
  • Infection
  • Inflammation Of The Bladder
  • Joint Pain
  • Low Sperm Count
  • Pink Eye
  • Ringing In The Ears
  • Stinging Of Skin
  • Swollen Lymph Nodes

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.