Methotrexate (Anti-Rheumatic) Tablet Side Effects by Likelihood and Severity

COMMON side effects


If experienced, these tend to have a Severe expression

  • A Bacterial Infection
  • A Systemic Inflammatory Response Called Sepsis Due To An Infection With Bacteria
  • Abnormal Liver Function Tests
  • Abnormally High Levels Of Nitrogen-Containing Compounds In Your Blood
  • Bleeding Of The Stomach Or Intestines
  • Canker Sores
  • Decreased Blood Platelets
  • Inflammation Of The Lining Of The Stomach And Intestines
  • Low Levels Of White Blood Cells
  • Stomach Or Intestinal Ulcer

If experienced, these tend to have a Less Severe expression

  • A Feeling Of General Discomfort Called Malaise
  • A Stinging Sensation On The Skin
  • Bronchitis
  • Decreased Appetite
  • Dizziness
  • Hair Loss
  • Headache
  • Inflammation Of The Gums And Mouth
  • Intense Abdominal Pain
  • Low Energy
  • Nausea

INFREQUENT side effects


If experienced, these tend to have a Severe expression

  • A Condition Where There Is Formation Of Fibrous Tissue In The Lung Called Pulmonary Fibrosis
  • Anemia
  • Damage To The Liver And Inflammation
  • Hardening Of The Liver
  • Inflammation Of The Arachnoid, One Of The Membranes Covering The Brain And Spinal Column
  • Leukoencephalopathy, A Disease Of The White Matter Of The Brain
  • Liver Tissue Death

If experienced, these tend to have a Less Severe expression

  • A Skin Rash
  • Chills
  • Diarrhea
  • Fever
  • Furunculosis Or Boils On The Skin
  • Itching
  • Throat Irritation
  • Vomiting

RARE side effects


If experienced, these tend to have a Severe expression

  • A Blood Clot In A Retinal Vein
  • A Blood Clot In An Artery
  • A Blood Clot In The Brain
  • A Broken Bone
  • A Clot In The Lung
  • A Hole In The Intestine
  • A Significant Type Of Allergic Reaction Called Anaphylaxis
  • A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome
  • A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis
  • A Type Of Blood Disorder With A Decrease In All Types Of Blood Cells Called Pancytopenia
  • A Type Of Brain Function Problem Called Encephalopathy
  • A Type Of Inflammation Of The Lung Called Interstitial Pneumonitis
  • Acute Liver Failure
  • An Increase In Uric Acid Due To Cancer Chemotherapy
  • An Unusual Viral Infection Called Cytomegalovirus Infection
  • Bleeding From The Lungs
  • Blood Clot In A Deep Vein Of The Extremities
  • Dead Skin
  • Decreased Kidney Function
  • Diabetes
  • Elevation Of Proteins In The Urine
  • Erythema Multiforme, A Type Of Allergic Skin Reaction
  • Excess Liver Fibrous Tissue
  • Fluid In The Covering Of The Heart Or Pericardium
  • Hemiplegia
  • Increased Eosinophils In The Blood
  • Increased Sensitivity Of The Skin To The Sun
  • Increased Spinal Fluid Pressure
  • Inflammation Of Blood Vessels In The Skin
  • Inflammation Of The Alveoli Of The Lungs
  • Inflammation Of The Covering Of The Heart Or Pericardium
  • Kidney Failure
  • Low Blood Counts Due To Bone Marrow Failure
  • Low Levels Of A Type Of White Blood Cell Called Neutrophils
  • Lung Failure Causing Loss Of Breath
  • Obstruction Of A Blood Vessel By A Blood Clot
  • Opportunistic Fungal Infection
  • Osteonecrosis, The Death Of Bone Tissue Due To A Lack Of Blood Supply
  • Pancreatitis
  • Pneumonia With A Fungus Called Pneumocystis Jirovecii
  • Seizures
  • Skin Rash With Sloughing
  • Subacute Necrotizing Encephalomyelopathy, A Type Of Brain Dysfunction
  • Temporary Blindness
  • Thrombophlebitis, An Inflamed Vein Due To A Blood Clot
  • Very Low Levels Of Granulocytes, A Type Of White Blood Cell

If experienced, these tend to have a Less Severe expression

  • A Problem With Menstrual Periods
  • A Type Of Speech Disorder Called Dysarthria
  • Acne
  • Altered Interest In Having Sexual Intercourse
  • An Infection
  • Aphasia, A Loss Of The Ability To Speak And Understand Language
  • Black Tarry Stools
  • Bloody Urine
  • Blurred Vision
  • Confusion
  • Drowsiness
  • Inflammation Of The Bladder
  • Joint Pain
  • Low Sperm Count
  • Muscle Pain
  • Pink Eye
  • Ringing In The Ears
  • Small Red Skin Lesions Due To Dilated Blood Vessels
  • Stomatitis, A Condition With Painful Swelling And Sores Inside The Mouth
  • Swollen Lymph Nodes

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.