Avatrombopag/Dual Inhibitors of CYP2C9 & CYP3A4 Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your medicine may slow down how quickly your body processes avatrombopag.

What might happen:

The amount of avatrombopag in your body may increase and cause increased side effects.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know right away if you have any signs of a blood clot (swelling or pain in your legs, shortness of breath, chest pain, stomach pain, or fast heartbeat). Also let your doctor know if you have fever, bruising, bleeding, tiredness, nausea, or headache.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Doptelet (avatrombopag) US prescribing information. Dova Pharmaceuticals August, 2020.
  • 2.Nomoto M, Zamora CA, Schuck E, Boyd P, Chang MK, Aluri J, Siu YA, Lai WG, Yasuda S, Ferry J, Rege B. Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs. Br J Clin Pharmacol 2018 May; 84(5):952-960.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.