Does Fluconazole Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • MISC ANTIFUNGAL AGENTS/ASTEMIZOLE; TERFENADINE
  • MODERATE CYP3A4 INHIBITORS/LUMATEPERONE (>21 MG)
  • MODERATE CYP3A4 INHIBITORS/MITAPIVAT (> 20 MG)
  • DUAL STRONG OR MODERATE CYP2C19 & 3A4 INHIBITORS/MAVACAMTEN
  • QT PROLONGING AGENTS/LEVOKETOCONAZOLE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LONAFARNIB
  • STRONG & MOD 2C19 INHIB THAT PROLONG QT/CILOSTAZOL (> 50 MG)
  • STRONG AND MODERATE CYP3A4 INHIBITORS/ASUNAPREVIR
  • QT PROLONGING AGENTS/HYDROXYCHLOROQUINE
  • STRONG OR MODERATE CYP3A4 INHIBITORS/LOMITAPIDE
  • MODERATE CYP3A4 INHIBITORS/NALOXEGOL (> 12.5 MG)
  • FLUCONAZOLE/ERYTHROMYCIN
  • QT PROLONGING AGENTS/ANAGRELIDE
  • MODERATE CYP3A4 INHIBITORS/RANOLAZINE (> 500 MG BID)
  • MODERATE CYP3A4 INHIBITORS/AVANAFIL (> 50 MG)
  • STRONG OR MODERATE CYP3A4 INHIBITORS/FLIBANSERIN
  • FLUCONAZOLE/FLUVASTATIN (> 20 MG BID)
  • QT PROLONGING AGENTS/DOMPERIDONE
  • FLUCONAZOLE/LURASIDONE (> 80 MG)
  • QT PROLONGING AGENTS/DRONEDARONE
  • QT PROLONGING AGENTS/ARTEMETHER-LUMEFANTRINE
  • SELECTED CYP3A4 INHIBITORS/VARDENAFIL (> 5 MG)
  • QT PROLONGING AGENTS/SERTINDOLE
  • QT PROLONGING AGENTS/DROPERIDOL
  • QT PROLONGING AGENTS/LEVOMETHADYL
  • QT PROLONGING AGENTS/SPARFLOXACIN
  • QT PROLONGING AGENTS/HALOFANTRINE
  • QT PROLONGING AGENTS/BEPRIDIL
  • SELECTED AZOLE ANTIFUNGALS/DISOPYRAMIDE; QUINIDINE
  • SELECTED AZOLE ANTIFUNGALS/PIMOZIDE
  • FLUCONAZOLE; MICONAZOLE/CISAPRIDE

    • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • SELECT AZOLE ANTIFUNGAL AGENTS/COUMARIN ANTICOAGULANTS
  • AZOLE ANTIFUNGAL AGENTS/SELECTED RIFAMYCINS
  • FLUCONAZOLE/QT PROLONGING AGENTS
  • AZOLE ANTIFUNGAL AGENTS/RIFABUTIN
  • SELECTED AZOLE ANTIFUNGAL AGENTS/TACROLIMUS
  • FLUCONAZOLE; VORICONAZOLE/DIAZEPAM
  • FLUCONAZOLE/CITALOPRAM; ESCITALOPRAM
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/PACRITINIB
  • DUAL MODERATE TO STRONG CYP2C9 AND CYP2C19 INHIB/ABROCITINIB
  • QT PROLONGING AGENTS/PANOBINOSTAT
  • SELECT CYP3A4 INHIBITORS THAT PROLONG QT/TRAZODONE
  • STRONG & MODERATE 3A4 INHIB THAT PROLONG QT/ENCORAFENIB
  • SELECTED QT PROLONGING AGENTS/INTRAVENOUS LEFAMULIN
  • MODERATE 3A4 INHIBITORS THAT PROLONG QT/MOBOCERTINIB
  • STRONG & MODERATE 3A4 INHIBITOR THAT PROLONG QT/FEXINIDAZOLE
  • DUAL MODERATE CYP2C9 & CYP3A4 INHIBITORS/MACITENTAN
  • STRONG AND MODERATE CYP3A4 INHIBITORS/INFIGRATINIB
  • SELECTED MODERATE CYP3A4 INHIBITORS/ALPRAZOLAM
  • FLUCONAZOLE/LORLATINIB
  • MODERATE CYP3A4 INHIBITORS/VOCLOSPORIN
  • QT PROLONGING AGENTS/LEVOMEPROMAZINE
  • FLUCONAZOLE/BOSENTAN
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LURBINECTEDIN
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/SELPERCATINIB
  • MODERATE CYP3A4 INHIBITORS/PEXIDARTINIB
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/IVABRADINE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/PEMIGATINIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/SELUMETINIB
  • QT PROLONGING AGENTS/OXALIPLATIN
  • MODERATE CYP3A4 INHIBITORS/TAZEMETOSTAT
  • STRONG AND MODERATE CYP3A4 INHIBITORS/LEMBOREXANT
  • MODERATE CYP3A4 INHIBITORS/ELEXACAFTOR-TEZACAFTOR-IVACAFTOR
  • STRONG & MOD CYP3A4 INHIBITOR THAT PROLONG QT/ORAL LEFAMULIN
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/ENTRECTINIB
  • DUAL INHIBITORS OF CYP2C19 & CYP3A4/FEDRATINIB
  • DUAL INHIBITORS OF CYP2C9 & CYP3A4/AVATROMBOPAG
  • DUAL INHIBITORS OF CYP2C9 & CYP3A4/SIPONIMOD
  • MODERATE CYP3A4 INHIBITORS/BRIGATINIB
  • QT PROLONGING AGENTS/GLASDEGIB
  • QT PROLONGING AGENTS/LOFEXIDINE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/TEZACAFTOR-IVACAFTOR
  • QT PROLONGING AGENTS/MACIMORELIN
  • QT PROLONGING AGENTS/INOTUZUMAB OZOGAMICIN
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/QUETIAPINE
  • QT PROLONGING AGENTS/RIBOCICLIB
  • STRONG AND MODERATE CYP3A4 INHIBITORS/DEFLAZACORT
  • QT PROLONGING AGENTS/HYDROXYZINE
  • QT PROLONGING AGENTS/PIMAVANSERIN
  • MODERATE CYP3A4 INHIBITORS/VENETOCLAX
  • QT PROLONGING AGENTS/VEMURAFENIB
  • QT PROLONGING AGENTS/TELAVANCIN
  • QT PROLONGING AGENTS/SORAFENIB
  • QT PROLONGING AGENTS/ROMIDEPSIN
  • QT PROLONGING AGENTS/ONDANSETRON
  • QT PROLONGING AGENTS/LENVATINIB
  • QT PROLONGING AGENTS/GADOFOSVESET
  • QT PROLONGING AGENTS/EZOGABINE
  • QT PROLONGING AGENTS/CERITINIB
  • QT PROLONGING AGENTS/BEDAQUILINE
  • QT PROLONGING AGENTS/OSIMERTINIB
  • QT PROLONGING AGENTS/DONEPEZIL
  • QT PROLONGING AGENTS/CHLORPROMAZINE
  • QT PROLONGING AGENTS/CHLOROQUINE
  • QT PROLONGING AGENTS/AZITHROMYCIN
  • QT PROLONGING AGENTS/SOTALOL
  • QT PROLONGING AGENTS/PROCAINAMIDE
  • QT PROLONGING AGENTS/IBUTILIDE
  • QT PROLONGING AGENTS/FLECAINIDE
  • MODERATE CYP3A4 INHIBITORS/NALOXEGOL (<= 12.5 MG)
  • QT PROLONGING AGENTS/DELAMANID
  • MODERATE CYP3A4 INHIBITORS/COBIMETINIB; OLAPARIB; SONIDEGIB
  • FLUCONAZOLE/RUXOLITINIB
  • STRONG & MODERATE CYP3A4 INHIBITORS/ELIGLUSTAT
  • MODERATE CYP3A4 INHIBITORS/SUVOREXANT (> 10 MG)
  • MODERATE CYP3A4 INHIBITORS/ERGOT ALKALOIDS
  • STRONG & MODERATE CYP3A4 INHIBITORS/GUANFACINE
  • FLUCONAZOLE/SLT ANTINEO SYSTEMIC ENZYME INHIBITORS
  • STRONG OR MODERATE CYP3A4 INHIBITORS/SIMEPREVIR
  • FLUCONAZOLE; VORICONAZOLE/OSPEMIFENE
  • STRONG; SELECTED MODERATE CYP2C19 INHIBITORS/CLOBAZAM
  • SELECTED INHIBITORS OF BOTH CYP3A4 AND CYP2C19/TOFACITINIB
  • MODERATE CYP3A4 INHIBITORS/BOSUTINIB
  • FLUCONAZOLE; VORICONAZOLE/LEVOMETHADONE; METHADONE
  • STRONG AND MODERATE CYP3A4 INHIBITORS/IVACAFTOR
  • QT PROLONGING AGENTS/VANDETANIB
  • QT PROLONGING AGENTS/MOXIFLOXACIN
  • FLUCONAZOLE/VORICONAZOLE
  • QT PROLONGING AGENTS/PROPAFENONE
  • QT PROLONGING AGENTS/SAQUINAVIR
  • QT PROLONGING AGENTS/QUININE
  • QT PROLONGING AGENTS/ILOPERIDONE
  • FLUCONAZOLE; KETOCONAZOLE; VORICONAZOLE/CLOPIDOGREL
  • QT PROLONGING AGENTS/LOPINAVIR
  • QT PROLONGING AGENTS/TOREMIFENE
  • MODERATE CYP3A4 INHIBITORS/COLCHICINE
  • MODERATE CYP3A4 INHIBITORS/TOLVAPTAN
  • QT PROLONGING AGENTS/ZUCLOPENTHIXOL
  • SLT AZOLE ANTIFUNGALS/SELECTED ANTICONVULSANTS; BARBITURATES
  • QT PROLONGING AGENTS/PALIPERIDONE
  • SELECTED QT PROLONGING AGENTS/ZIPRASIDONE
  • SELECTED CYP3A4 INHIBITORS/SELECTED OPIOIDS
  • QT PROLONGING AGENTS/AMIODARONE
  • SELECTED MODERATE CYP3A4 INHIBITORS/EPLERENONE
  • QT PROLONGING AGENTS/MESORIDAZINE
  • QT PROLONGING AGENTS/THIORIDAZINE
  • SELECTED AZOLE ANTIFUNGAL AGENTS/SELECTED IMMUNOSUPPRESSANTS

    • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • AZOLE ANTIFUNGALS/SULFONYLUREAS
  • FLUCONAZOLE/SELECTED QT PROLONGING AGENTS
  • FLUCONAZOLE/POSSIBLE QT PROLONGING AGENTS
  • QT PROLONGING AGENTS/TUCIDINOSTAT
  • MODERATE CYP3A4 INHIBITORS/LUMATEPERONE (<=21 MG)
  • FLUCONAZOLE; VORICONAZOLE/SELECTED BENZODIAZEPINES
  • QT PROLONGING AGENTS/TRICLABENDAZOLE
  • MODERATE CYP3A4 INHIBITORS/MITAPIVAT (<= 20 MG)
  • MODERATE CYP3A4 INHIBITORS/DARIDOREXANT
  • STRONG CYP2C19 INHIBITORS/BELZUTIFAN
  • QT PROLONGING AGENTS/OZANIMOD
  • QT PROLONGING AGENTS/PONESIMOD
  • QT PROLONGING AGENTS/GALANTAMINE
  • MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/IVOSIDENIB
  • QT PROLONGING AGENTS/OSILODROSTAT
  • QT PROLONGING AGENTS/AMISULPRIDE
  • MODERATE CYP3A4 INHIBITORS/RIMEGEPANT
  • MODERATE CYP3A4 INHIBITORS/AVAPRITINIB
  • MODERATE CYP3A4 INHIBITORS/UBROGEPANT
  • MODERATE CYP3A4 INHIBITORS/ZANUBRUTINIB
  • ERYTHROMYCIN; FLUCONAZOLE; ROXITHROMYCIN/TRIAZOLAM
  • QT PROLONGING AGENTS/PITOLISANT
  • QT PROLONGING AGENTS/GILTERITINIB
  • MODERATE CYP3A4 INHIBITORS/ABEMACICLIB
  • MODERATE CYP3A4 INHIBITORS/CABERGOLINE
  • SELECTED MODERATE CYP3A4 INHIBITORS/ACALABRUTINIB
  • FLUCONAZOLE/APIXABAN; DABIGATRAN; RIVAROXABAN
  • QT PROLONGING AGENTS/EFAVIRENZ
  • MODERATE CYP3A4 INHIBITORS/BROMOCRIPTINE
  • MODERATE CYP2C9 INHIBITORS/LESINURAD
  • QT PROLONGING AGENTS/ERIBULIN
  • MODERATE CYP3A4 INHIBITORS/BREXPIPRAZOLE
  • FLUCONAZOLE (<= 150 MG)/TRAZODONE
  • MODERATE CYP3A4 INHIBITORS/SUVOREXANT (<= 10 MG)
  • MODERATE CYP3A4 INHIBITORS/AVANAFIL (<= 50 MG)
  • MODERATE CYP3A4 INHIBITORS/IBRUTINIB
  • QT PROLONGING AGENTS/FINGOLIMOD
  • FLUCONAZOLE/AMITRIPTYLINE
  • FLUCONAZOLE/SELECTED HMG CO-A REDUCTASE INHIBITORS
  • SELECTED CYP3A4 INHIBITORS/VARDENAFIL (<= 5 MG)
  • FLUCONAZOLE/LURASIDONE (<= 80 MG)
  • FLUCONAZOLE (>= 200 MG)/TIPRANAVIR
  • SELECTED AZOLE ANTIFUNGALS/SELECTED CALCIUM CHANNEL BLOCKERS
  • MODERATE CYP3A4; P-GP INHIBITORS/EVEROLIMUS
  • MODERATE CYP3A4 INHIBITORS/RANOLAZINE (<=500 MG BID)
  • SELECTED AZOLE ANTIFUNGALS/FELODIPINE; NISOLDIPINE
  • SELECTED CYP2C9 INHIBITORS/SELECTED NSAIDS
  • STRONG & MOD 2C19 INHIB THAT PROLONG QT/CILOSTAZOL (<=50MG)
    • Full Drug Information

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    Drug Survey

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    This survey is being conducted by the WebMD marketing sciences department.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.