Does Fluconazole Interact with other Medications?
Severe Interactions
These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
- MISC ANTIFUNGAL AGENTS/ASTEMIZOLE; TERFENADINE
- STRONG OR MODERATE CYP3A4 INHIBITORS/LOMITAPIDE
- MODERATE CYP3A4 INHIBITORS/NALOXEGOL (> 12.5 MG)
- FLUCONAZOLE/ERYTHROMYCIN
- QT PROLONGING AGENTS/ANAGRELIDE
- MODERATE CYP3A4 INHIBITORS/RANOLAZINE (> 500 MG BID)
- MODERATE CYP3A4 INHIBITORS/AVANAFIL (> 50 MG)
- STRONG OR MODERATE CYP3A4 INHIBITORS/FLIBANSERIN
- FLUCONAZOLE/FLUVASTATIN (> 20 MG BID)
- QT PROLONGING AGENTS/DOMPERIDONE
- FLUCONAZOLE/LURASIDONE (> 80 MG)
- QT PROLONGING AGENTS/AMIFAMPRIDINE
- QT PROLONGING AGENTS/DRONEDARONE
- QT PROLONGING AGENTS/ARTEMETHER-LUMEFANTRINE
- SELECTED CYP3A4 INHIBITORS/VARDENAFIL (> 5 MG)
- QT PROLONGING AGENTS/SERTINDOLE
- QT PROLONGING AGENTS/DROPERIDOL
- QT PROLONGING AGENTS/LEVOMETHADYL
- QT PROLONGING AGENTS/SPARFLOXACIN
- QT PROLONGING AGENTS/HALOFANTRINE
- QT PROLONGING AGENTS/BEPRIDIL
- SELECTED AZOLE ANTIFUNGALS/DISOPYRAMIDE; QUINIDINE
- SELECTED AZOLE ANTIFUNGALS/PIMOZIDE
- FLUCONAZOLE; MICONAZOLE/CISAPRIDE
Serious Interactions
These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
- SELECT AZOLE ANTIFUNGAL AGENTS/COUMARIN ANTICOAGULANTS
- FLUCONAZOLE/QT PROLONGING AGENTS
- QT PROLONGING AGENTS/LOFEXIDINE
- STRONG AND MODERATE CYP3A4 INHIBITORS/TEZACAFTOR-IVACAFTOR
- QT PROLONGING AGENTS/MACIMORELIN
- STRONG AND MODERATE CYP2C9 INHIBITORS/BOSENTAN
- QT PROLONGING AGENTS/INOTUZUMAB OZOGAMICIN
- STRONG AND MODERATE CYP3A4 INHIBITORS/NERATINIB
- MODERATE CYP3A4 INHIBITORS THAT PROLONG QT/QUETIAPINE
- QT PROLONGING AGENTS/RIBOCICLIB
- STRONG AND MODERATE CYP3A4 INHIBITORS/DEFLAZACORT
- QT PROLONGING AGENTS/HYDROXYZINE
- QT PROLONGING AGENTS/PIMAVANSERIN
- MODERATE CYP3A4 INHIBITORS/VENETOCLAX
- QT PROLONGING AGENTS/VEMURAFENIB
- QT PROLONGING AGENTS/TELAVANCIN
- QT PROLONGING AGENTS/SORAFENIB
- QT PROLONGING AGENTS/ROMIDEPSIN
- QT PROLONGING AGENTS/ONDANSETRON
- QT PROLONGING AGENTS/LENVATINIB
- QT PROLONGING AGENTS/GADOFOSVESET
- QT PROLONGING AGENTS/EZOGABINE
- QT PROLONGING AGENTS/ERIBULIN
- QT PROLONGING AGENTS/CERITINIB
- QT PROLONGING AGENTS/BEDAQUILINE
- QT PROLONGING AGENTS/OSIMERTINIB
- QT PROLONGING AGENTS/DONEPEZIL
- QT PROLONGING AGENTS/CILOSTAZOL
- QT PROLONGING AGENTS/CHLORPROMAZINE
- QT PROLONGING AGENTS/CHLOROQUINE
- QT PROLONGING AGENTS/AZITHROMYCIN
- QT PROLONGING AGENTS/SOTALOL
- QT PROLONGING AGENTS/PROCAINAMIDE
- QT PROLONGING AGENTS/IBUTILIDE
- QT PROLONGING AGENTS/FLECAINIDE
- MODERATE CYP3A4 INHIBITORS/NALOXEGOL (<= 12.5 MG)
- QT PROLONGING AGENTS/DELAMANID
- MODERATE CYP3A4 INHIBITORS/COBIMETINIB; OLAPARIB; SONIDEGIB
- FLUCONAZOLE/RUXOLITINIB
- STRONG & MODERATE CYP3A4 INHIBITORS/ELIGLUSTAT
- MODERATE CYP3A4 INHIBITORS/SUVOREXANT > 10 MG
- MODERATE CYP3A4 INHIBITORS/ERGOTAMINE DERIVATIVES
- STRONG & MODERATE CYP3A4 INHIBITORS/GUANFACINE
- FLUCONAZOLE/SLT ANTINEO SYSTEMIC ENZYME INHIBITORS
- STRONG OR MODERATE CYP3A4 INHIBITORS/SIMEPREVIR
- STRONG AND MODERATE CYP3A4 INHIBITORS/BOSENTAN
- FLUCONAZOLE; VORICONAZOLE/OSPEMIFENE
- STRONG; SELECTED MODERATE CYP2C19 INHIBITORS/CLOBAZAM
- SELECTED INHIBITORS OF BOTH CYP3A4 AND CYP2C19/TOFACITINIB
- MODERATE 3A4 INHIBITORS/BOSUTINIB
- FLUCONAZOLE; VORICONAZOLE/METHADONE
- STRONG AND MODERATE CYP3A4 INHIBITORS/IVACAFTOR
- SELECT CYP2C19 INHIBITORS/CITALOPRAM (>20 MG)
- QT PROLONGING AGENTS/VANDETANIB
- QT PROLONGING AGENTS/MOXIFLOXACIN
- FLUCONAZOLE/VORICONAZOLE
- QT PROLONGING AGENTS/PROPAFENONE
- QT PROLONGING AGENTS/SAQUINAVIR
- QT PROLONGING AGENTS/VINFLUNINE
- QT PROLONGING AGENTS/QUININE
- QT PROLONGING AGENTS/ILOPERIDONE
- FLUCONAZOLE; KETOCONAZOLE; VORICONAZOLE/CLOPIDOGREL
- QT PROLONGING AGENTS/LOPINAVIR
- QT PROLONGING AGENTS/ASENAPINE
- QT PROLONGING AGENTS/TOREMIFENE
- MODERATE CYP3A4 INHIBITORS/COLCHICINE
- MODERATE CYP3A4 INHIBITORS/TOLVAPTAN
- QT PROLONGING AGENTS/TETRABENAZINE
- QT PROLONGING AGENTS/ZUCLOPENTHIXOL
- SELECTED AZOLE ANTIFUNGALS/CARBAMAZEPINE; HYDANTOINS
- QT PROLONGING AGENTS/PALIPERIDONE
- MODERATE CYP3A4 INHIBITORS/IVABRADINE
- SELECTED QT PROLONGING AGENTS/ZIPRASIDONE
- SLT 3A4 INHIBIT/ALFENTANIL; FENTANYL; HYDROCODONE; OXYCODONE
- QT PROLONGING AGENTS/AMIODARONE
- SELECTED CYP3A4 INHIBITORS/TRAZODONE
- SELECTED MODERATE CYP3A4 INHIBITORS/EPLERENONE
- QT PROLONGING AGENTS/MESORIDAZINE
- QT PROLONGING AGENTS/THIORIDAZINE
- SELECTED AZOLE ANTIFUNGAL AGENTS/SELECTED IMMUNOSUPPRESSANTS
Moderate Interactions
These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.
- AZOLE ANTIFUNGALS/SULFONYLUREAS
- AZOLE ANTIFUNGAL AGENTS/RIFAMYCINS
- FLUCONAZOLE/SELECTED QT PROLONGING AGENTS
- FLUCONAZOLE/POSSIBLE QT PROLONGING AGENTS
- QT PROLONGING AGENTS/DEUTETRABENAZINE
- MODERATE CYP3A4 INHIBITORS/CABERGOLINE
- MODERATE 3A4 INHIBITORS/ACALABRUTINIB
- FLUCONAZOLE/APIXABAN; DABIGATRAN; RIVAROXABAN
- QT PROLONGING AGENTS/HYDROXYCHLOROQUINE
- QT PROLONGING AGENTS/EFAVIRENZ
- MODERATE CYP3A4 INHIBITORS/BROMOCRIPTINE
- MODERATE CYP2C9 INHIBITORS/LESINURAD
- MODERATE CYP3A4 INHIBITORS/BREXPIPRAZOLE
- FLUCONAZOLE (=< 150 MG)/TRAZODONE
- MODERATE CYP3A4 INHIBITORS/SUVOREXANT <= 10 MG
- MODERATE CYP3A4 INHIBITORS/AVANAFIL (<= 50 MG)
- MODERATE 3A4 INHIBITORS/IBRUTINIB
- FLUCONAZOLE/AMITRIPTYLINE
- FLUCONAZOLE/SELECTED HMG CO-A REDUCTASE INHIBITORS
- SELECTED CYP2C19 INHIBITORS/CITALOPRAM (<= 20 MG)
- SELECTED CYP3A4 INHIBITORS/VARDENAFIL (<= 5 MG)
- FLUCONAZOLE/LURASIDONE (<= 80 MG)
- FLUCONAZOLE/TIPRANAVIR
- SELECTED AZOLE ANTIFUNGALS/SELECTED CALCIUM CHANNEL BLOCKERS
- MODERATE CYP3A4; P-GP INHIBITORS/EVEROLIMUS
- MODERATE CYP3A4 INHIBITORS/RANOLAZINE (<=500 MG BID)
- SELECTED AZOLE ANTIFUNGALS/FELODIPINE; NISOLDIPINE
- SELECTED CYP2C9 INHIBITORS/SELECTED NSAIDS
- SELECTED AZOLE ANTIFUNGALS/SELECTED BENZODIAZEPINES
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.