Glimepiride; Glipizide; Glyburide/Colesevelam Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Colesevelam may bind to your diabetes medicine in your GI tract, preventing your body from absorbing the medicine.
What might happen:
The amount of your diabetes medicine in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. You should time your medicines so that you take your diabetes medicine 4 hours or more before your colesevelam. If you have any questions about how to take your medicines, ask your pharmacist. Your doctor may want you to check your blood glucose more frequently while you are taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Welchol (colesevelam hydrochloride) US prescribing information. Daiichi Sankyo, Inc. January 22, 2014.
- 2.Brown KS, Armstrong IC, Wang A, Walker JR, Noveck RJ, Swearingen D, Allison M, Kissling JC, Kisicki J, Salazar DE. Effect of the bile acid sequestrant colesevelam on the pharmacokinetics of pioglitazone, repaglinide, estrogen estradiol, norethindrone, levothyroxine, and glyburide. J Clin Pharmacol 2010 May;50(5):554-65.
- 3.Diabeta (glyburide) US prescribing information. Sanofi-Aventis U.S. LLC October, 2013.
- 4.Amaryl (glimepiride) US prescribing information. Sanofi-Aventis U.S. LLC October, 2013.