Oral Iron Supplements/Selected Minerals Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Iron may bind to other minerals in your GI tract, which may prevent them from being absorbed.
What might happen:
The amount of minerals you absorb from your supplement may decrease.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Do not take your iron supplement within 1 hour before or 2 hours after products containing calcium, manganese, tin, or zinc. Your doctor may want to check your blood to see if your levels of iron or other minerals are low.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Ferrous gluconate US prescribing information. GFR Nutritionals Ltd September 29, 2003.
- 2.Cook JD, Dassenko SA, Whittaker P. Calcium supplementation: effect on iron absorption. Am J Clin Nutr 1991 Jan;53(1):106-11.
- 3.Pruchnicki MC, Coyle JD, Hoshaw-Woodard S, Bay WH. Effect of phosphate binders on supplemental iron absorption in healthy subjects. J Clin Pharmacol 2002 Oct;42(10):1171-6.
- 4.Rossander-Hulten L, Brune M, Sandstrom B, Lonnerdal B, Hallberg L. Competitive inhibition of iron absorption by manganese and zinc in humans. Am J Clin Nutr 1991 Jul;54(1):152-6.
- 5.Valberg LS, Flanagan PR, Chamberlain MJ. Effects of iron, tin, and copper on zinc absorption in humans. Am J Clin Nutr 1984 Sep;40(3):536-41.
- 6.Solomons NW, Jacob RA. Studies on the bioavailability of zinc in humans: effects of heme and nonheme iron on the absorption of zinc. Am J Clin Nutr 1981 Apr;34(4):475-82.
- 7.Friel JK, Serfass RE, Fennessey PV, Miller LV, Andrews WL, Simmons BS, Downton GF, Kwa PG. Elevated intakes of zinc in infant formulas don not interfere with iron absorption in premature infants. J Pediatr Gastroenterol Nutr 1998 Sep;27(3):312-6.