Nefazodone/Carbamazepine Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Carbamazepine may increase how quickly your body processes nefazodone. Nefazodone may decrease how quickly your body processes carbamazepine.

What might happen:

The amount of nefazodone in your blood may decrease and it may not work as well for your condition. The amount of carbamazepine in your blood may increase and cause side effects, including drowsiness, dizziness, blurred vision, or loss of coordination.

What you should do about this interaction:

Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these medicines together. If your nefazodone is not working, your doctor may want to change your medication. Your doctor may want to check the amount of carbamazepine in your blood. Let your healthcare professionals know if you have any side effects from your carbamazepine. Your doctor may need to change your dose of carbamazepine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Serzone (nefazodone hydrochloride) US prescribing information. Bristol-Myers Squibb Company January, 2005.
  • 2.Tegretol (carbamazepine) US prescribing information. Novartis Pharmaceuticals Corporation March, 2018.
  • 3.Laroudie C, Salazar DE, Cosson JP, Cheuvart B, Istin B, Girault J, Ingrand I, Decourt JP. Carbamazepine-nefazodone interaction in healthy subjects. J Clin Psychopharmacol 2000 Feb;20(1):46-53.
  • 4.Ashton AK, Wolin RE. Nefazodone-induced carbamazepine toxicity. Am J Psychiatry 1996 May;153(5):733.
  • 5.Roth L, Bertschy G. Nefazodone may inhibit the metabolism of carbamazepine: three case reports. Eur Psychiatry 2001 Aug;16(5):320-1.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.