Digoxin, Oral/Acarbose Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Acarbose may decrease how much digoxin your body absorbs.

What might happen:

The amount of digoxin in your blood may decrease and it may not work as well. If you stop taking acarbose, the amount of digoxin in your blood may increase and cause extra side effects.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and if you stop taking acarbose. Your doctor may want to check the amount of digoxin in your blood and may need to change the dose of your digoxin.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Miura T, Ueno K, Tanaka K, Sugiura Y, Mizutani M, Takatsu F, Takano Y, Shibakawa M. Impairment of absorption of digoxin by acarbose. J Clin Pharmacol 1998 Jul;38(7):654-7.
  • 2.Lanoxin (digoxin) Tablets US prescribing information. Covis Pharmaceuticals, Inc. August, 2018.
  • 3.Cohen E, Almog S, Staruvin D, Garty M. Do therapeutic doses of acarbose alter the pharmacokinetics of digoxin?. Isr Med Assoc J 2002 Oct; 4(10):772-5.
  • 4.Nagai Y, Hayakawa T, Abe T, Nomura G. Are there different effects of acarbose and voglibose on serum levels of digoxin in a diabetic patient with congestive heart failure?. Diabetes Care 2000 Nov;23(11):1703.
  • 5.Ben-Ami H, Krivoy N, Nagachandran P, Roguin A, Edoute Y. An interaction between digoxin and acarbose. Diabetes Care 1999 May;22(5):860-1.
  • 6.Serrano JS, Jimenez CM, Serrano MI, Balboa B. A possible interaction of potential clinical interest between digoxin and acarbose. Clin Pharmacol Ther 1996 Nov;60(5):589-92.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.